Systematic CRISPR screens in primary CD4+ T cells identified 30+ pro/anti-HIV factors, revealing diverse mechanisms that could inform targeted therapies against HIV! PMID:42013838, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600382X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Exciting advances in CB1 agonist design! Two Gi-biased compounds, LZD503 and LZD505, reduce side effects by fine-tuning molecular interactions. Non-opioid therapy potential grows! PMID:41980782, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00287-4 #Medsky #Pharmsky #RNA #ASHG 🧪

New study maps cellular senescence in humans, revealing 100+ distinct "senotypes" linked to aging/disease. Insights blend AI, multi-omics for targeted therapies! PMID:42276030, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00587-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

KRAS, a key driver in cancer, undergoes farnesylation, forming phase-separated condensates that promote colon tumor growth and are linked to poor outcomes. PMID:42202789, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00519-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

CANVAS leverages AI to analyze >18M cells from H&E histopathology, revealing tumor microenvironment architecture that drives disease progression & therapy resistance. PMID:42302781, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00590-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Karyoptosis, a unique cell death form, drives neuron death under proteotoxic stress, beyond apoptosis—could it be key to neurodegeneration? Read on for insights! PMID:42350373, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-73802-w #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New research reveals 2 clades of SARS-CoV-2-related coronaviruses in Thai bats, one effectively binding human ACE2. Key for understanding viral evolution & spillover risks! PMID:42097139, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600454X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

p53 is crucial for safe reprogramming of somatic cells into pluripotent states, balancing genomic stability with Yamanaka factors to mitigate risks. #CellReprogramming PMID:41999746, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00339-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New research reveals a family of 4 hibernation factors (SriA-SriD) in the archaeon Methanosarcina acetivorans, protecting ribosomes under stress for efficient dormancy. PMID:42350466, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74727-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Discover how 9 cortical & 4 subcortical phenotypes unravel brain structure changes in OCD. Study reveals unique regional shifts in a massive sample of 2255 OCD & 2264 controls. PMID:42343090, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74153-2 #Medsky #Pharmsky #RNA #ASHG 🧪

Largest proteogenomic study (n=78,664) identifies >24,000 protein QTLs for 1,116 proteins, revealing genetic effects across pathways & cell types. Insightful advances! PMID:42097137, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00385-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Trial in NEJM: A 6-month regimen of bedaquiline, linezolid, delamanid & levofloxacin/clofazimine shows promise for rifampicin-resistant TB in South Africa for ages 6+. PMID:42341301, N Engl J Med 2026, @NEJM https://doi.org/10.1056/NEJMoa2503687 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A study reveals a 3D morphogenetic blueprint driving breast cancer metastasis. Macrometastases activate a gene program reminiscent of branching morphogenesis, essential for growth. PMID:41923644, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600276X #Medsky #Pharmsky #RNA #ASHG 🧪

New insights reveal the complex of BLTP VPS13A and scramblase XK, visualized by cryo-EM, enhances lipid transfer between organelles, crucial for cellular function. PMID:42285089, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Explore how the type III-D2 CRISPR-Cas system synthesizes dual messengers SAM-AMP & S… PMID:42342668, Nat Commun 2026, @NatureComms @OTSociety @NAR_Open https://doi.org/10.1038/s41467-026-74422-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A genome-scale genetic interaction map from HAP1 cells reveals ~89,000 high-confidence interactions, linking genes to protein complexes and enhancing gene co-essentiality insights. PMID:42049019, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00345-4 #Medsky #Pharmsky #RNA #ASHG 🧪

A study links autoantibodies (AABs) to neurological symptoms in long COVID (LC), showing increased AABs against CNS and PNS proteins in affected individuals. PMID:42208499, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600509X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Mind-blowing! 🌟 14 groups, 2,080 DNA hexamers, 190 20-mer duplexes, 10μs each = 0.25P… PMID:42342657, Nat Commun 2026, @NatureComms @OTSociety @NAR_Open https://doi.org/10.1038/s41467-026-74390-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New research maps 7 senotypes in human aging & disease using single-cell & spatial multi-omics. Findings pave the way for 5 targeted senotherapeutics! PMID:42276030, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00587-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Long-term SPT of EGFR, HER2, and HER3 reveals oncogenic EGFR mutations induce stable, ligand-independent dimerization, impacting ErbB signaling dynamics significantly. PMID:42054992, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00399-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪