Polyploidy is a key force in angiosperm evolution, with 132 ancient whole-genome duplication events identified across 470 species, revealing non-random clustering—fascinating! PMID:42105759, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00397-1 #Medsky #Pharmsky #RNA #ASHG 🧪

BsAb EVs target FAP⁺ fibroblasts in 1 surgical model, redirecting T cells to reduce epidural fibrosis effectively post-surgery. Potential game-changer for recovery! PMID:42364978, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74883-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

T cell activation triggers ADAM17-mediated cleavage via a 15-aa motif, enabling control over CAR expression. This innovation reduces CAR levels based on tonic signaling. PMID:42143019, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00504-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New research identifies E3 ubiquitin ligase MARCH7 as a crucial ferro-guardian against ferroptosis, regulating iron homeostasis by targeting NCOA4. PMID:42049018, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00388-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Moore et al, The rapid emergence of small molecule #RNA modulator hit discovery: unlocking the potential | Expert Opinion on #DrugDiscovery 2026 | #MedChem #DrugDesign #Free2Read #chemsky 🧪 doi.org/10.1080/1746...

The cGAS-STING pathway senses dsDNA, linking innate immunity and cellular responses. Key to antitumor immunity, it also drives inflammatory disorders. #Immunology #Research PMID:42349382, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00650-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Sex-specific and functional differentiation between OR23h and OR109d in aggregation pheromone detection in Riptortus pedestris
🎓led by Prof. Jin Zhang & Ian W. Keesey
✅https://doi.org/10.1016/j.jia.2025.11.009
#entomology #insect #BeanBug #RNA

Splenic macrophage-B cell axis in cerebral malaria drives systemic autoimmunity. CD36 autoantibodies, found in 97% of patients, target infected RBCs, causing pathological effects. PMID:42364976, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74882-4 #Medsky #Pharmsky #RNA #ASHG 🧪

A novel library of 84 CRISPR-Cas9 mouse lines enables in vivo screening of host factors in influenza A research, overcoming bottlenecks in functional validation. PMID:42302780, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600591X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Oligonucleotide medicines are breaking out of rare diseases thanks to breakthroughs in chemistry and delivery! 🧬🚀 How will programmable genetic meds shape the future of common conditions? www.news-medical.net/news/2026092... #Oligonucleotides #RNA #HealthTech

ERDRP-0519, a promising non-nucleoside polymerase inhibitor, showcases differential inhibition, effectively targeting Measles (MeV) and Nipah virus (NiV) RdRp, with potential for optimized interactions. PMID:42061399, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00400-9 #RNA 🧪

Recent findings reveal that MAP1B, a microtubule-associated protein, shuttles to the nucleus in neural stem cells, linking cytoskeletal dynamics to gene regulation and disease. PMID:42276043, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00578-7 #Medsky #Pharmsky #RNA #ASHG 🧪

Cysteine's sulfur is crucial for CD8⁺ T cell fate, driving 60% toward glutathione and 40% for iron-sulfur clusters, influencing proliferation and anti-tumor immunity. PMID:42276031, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00570-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

🦠🧬 Under stress, #bacteria can reshape interactions between #RNA and #proteins, revealing another layer of #gene regulation that helps #microbes rapidly adapt to changing conditions.

#Microbiology #Bacteria #RNA #MolecularBiology #Microsky via @sciencex.bsky.social

phys.org/news/2026-09...

AI-driven discovery identifies GPNMB CAR T cells as a promising multi-cancer therapy, refining targets through single-cell RNA seq from 100+ datasets. Exciting advancements ahead! PMID:42349383, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00651-3 #Medsky #Pharmsky #RNA #ASHG 🧪

It works!!!! 🤯😎🙌

#RNA 💚

Exploring SMVT with cryo-EM: 3 structures unveiled—occluded, outward-open, inward-open—reveal how it transports vital vitamins. Key to tackling its dysfunction! PMID:42364996, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74948-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

NAD+ modulates mitochondrial vulnerability in MERTK models of retinitis pigmentosa (R… PMID:42365006, Nat Commun 2026, @NatureComms @OTSociety @NAR_Open https://doi.org/10.1038/s41467-026-74400-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Major breakthrough in HIV research: CRISPR screens in primary CD4+ T cells identified multiple pro- and anti-HIV host factors, revealing diverse antiviral mechanisms! PMID:42013838, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600382X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Chloroplasts use MBS1 to sense singlet oxygen (¹O₂) and trigger photoprotection, revealing how plants manage high-light tolerance through protein condensates. PMID:42309053, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00642-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪