Check out PlanarFold: a new RNA model boosting simulation speed by over 10,000x with 2D coarse-grained dynamics, offering insights into RNA structures & dynamics! PMID:42362537, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74729-y #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Rational discovery led to small-molecule PAK1 activators, revealing a novel site for autoinhibition release, advancing cardiac therapy prospects. PMID:41923641, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00275-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New research reveals that parvalbumin-expressing (BF-PV) inhibitory neurons in the basal forebrain are crucial for sustaining attention, challenging prior views on cholinergic neurons. PMID:42349384, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600646X #Medsky #Pharmsky #RNA #ASHG 🧪

Re-admin of AAV1-hOTOF gene therapy, even amid peak NAb titers in Otof^-/- mice, improves OTOF-related deafness outcomes. PMID:42362868, Nat Med 2026, @NatureMedicine https://doi.org/10.1038/s41591-026-04505-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Cliramitug's long-term follow-up in trial NI006-101 shows lasting safety and efficacy with dose-dependent amyloid reduction in ATTR-CM patients over 12 months. PMID:42362866, Nat Med 2026, @NatureMedicine https://doi.org/10.1038/s41591-026-04487-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Late embryonic skin injuries can regenerate diverse tissues effectively, but this capacity diminishes post-birth, leading to hyperinnervation and incomplete healing. PMID:41864207, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00234-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study tackles disparities in dementia diagnosis: 7,847 participants reveal inconsistent machine learning performance across racial/ethnic groups, urging better fairness insights. PMID:42362543, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74515-w #Medsky #Pharmsky #RNA #ASHG 🧪

New research identifies MARCH7 as a key E3 ubiquitin ligase that stabilizes iron homeostasis, reducing ferroptosis via K48-linked ubiquitylation of NCOA4. PMID:42049018, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00388-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Submit your research by December 30 for JPET's upcoming collection, "Peptide-Based Therapeutics for Tumor Immunomodulation."

Learn more at https://ow.ly/a8hZ50ZPEEr
#pharmsky 🧪

Study shows that accumbal dopamine predicts preference: 2 types of reward cues trigger DA transients in 100% cases, declining at natural rewards and persisting with drugs. PMID:42362884, Nat Neurosci 2026, @NatureNeuro https://doi.org/10.1038/s41593-026-02331-y #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Humans evaluate info by relative evidence, not absolute uncertainty. AI models predict behavior. Fascinating insights! 🌟 PMID:42362882, Nat Neurosci 2026, @NatureNeuro https://doi.org/10.1038/s41593-026-02342-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A novel in vivo gene switch responsive to electromagnetic fields (EMFs) allows precise spatiotemporal gene expression control. Key findings reveal Cyb5b as an essential EMF sensor. PMID:41985457, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00330-2 #Medsky #Pharmsky #RNA #ASHG 🧪

Revolutionary study shows LEAPER 2.0 enabled long-term DMD reversal in monkeys & humans via circ-arRNA-guided exon skipping, spurring hope for treatment! #DuchenneMuscularDystrophy PMID:42269605, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00589-1 #Medsky #Pharmsky #RNA #ASHG 🧪

A new CRISPR knockout mouse library (84 lines) enables in vivo screening of host factors in influenza A research, bridging gaps in translation from in vitro studies. PMID:42302780, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600591X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A recent Cell study reveals autoantibodies in 25% of long COVID patients drive symptoms like pain, fatigue, & neurocognitive issues, highlighting disease complexity. PMID:42208496, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00511-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New insights reveal MAP1B, a microtubule-associated protein, shuttles to the nucleus in neural stem cells, linking cytoskeletal dynamics to cell fate and disease. PMID:42276043, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00578-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Research reveals that METHYLENE BLUE SENSITIVITY1 (MBS1), a zinc-finger protein, helps chloroplasts sense singlet oxygen (¹O₂) to boost photoprotection in high light. PMID:42309053, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00642-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New study reveals excessive vascular integrity in small-cell lung cancer creates an immune desert. "Reverse normalization" may boost immunotherapy efficacy—time to rethink strategies! PMID:42349379, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00634-3 #Medsky #Pharmsky #RNA 🧪

New study reveals mesenchymal drift as a unifying mechanism linking key aging hallmarks, showing how cells lose identity and adopt mesenchymal traits, fostering decline. PMID:42208498, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00455-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Discovery of Galvanin (TMEM154) reveals its critical role in electric-field-guided cell migration, shedding light on how 40% of immune cells navigate to wounds. PMID:42127892, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00461-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪