Engineered AAV9 vector targets SOD1 mutations in ALS, extending mouse survival. Gene silencing through a single IV dose shows promise for durable ALS treatment. PMID:42350385, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74169-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Rational strategies led to the discovery of small-molecule activators of PAK1, unlocking a new autoinhibition-release site crucial for cardiac health! PMID:41923641, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00275-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New method D&D-seq enables single-cell profiling of transient DNA-protein interactions, revealing key insights into transcription factor dynamics in gene regulation. PMID:42242226, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00573-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Exploring enzymatic recycling for nylon waste! Key barriers: biochemical, structural, materials science. Progress needed! PMID:42174226, Nat Chem Biol 2026, @nchembio https://doi.org/10.1038/s41589-026-02210-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Revolutionary approach using LEAPER 2.0 and circ-arRNAs achieved long-term exon skipping in DMD, showing promise in monkeys and humans for muscle recovery! PMID:42269605, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00589-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A study reveals that 78% of long COVID patients produce autoantibodies targeting CNS proteins, correlating with neurocognitive symptoms, signaling a potential pathogenic role. PMID:42208499, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600509X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Systematic CRISPR screens in primary CD4+ T cells identified 30+ pro/anti-HIV factors, revealing diverse mechanisms that could inform targeted therapies against HIV! PMID:42013838, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600382X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New study maps cellular senescence in humans, revealing 100+ distinct "senotypes" linked to aging/disease. Insights blend AI, multi-omics for targeted therapies! PMID:42276030, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00587-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

KRAS, a key driver in cancer, undergoes farnesylation, forming phase-separated condensates that promote colon tumor growth and are linked to poor outcomes. PMID:42202789, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00519-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

CANVAS leverages AI to analyze >18M cells from H&E histopathology, revealing tumor microenvironment architecture that drives disease progression & therapy resistance. PMID:42302781, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00590-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Karyoptosis, a unique cell death form, drives neuron death under proteotoxic stress, beyond apoptosis—could it be key to neurodegeneration? Read on for insights! PMID:42350373, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-73802-w #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New research reveals 2 clades of SARS-CoV-2-related coronaviruses in Thai bats, one effectively binding human ACE2. Key for understanding viral evolution & spillover risks! PMID:42097139, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600454X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

p53 is crucial for safe reprogramming of somatic cells into pluripotent states, balancing genomic stability with Yamanaka factors to mitigate risks. #CellReprogramming PMID:41999746, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00339-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New research reveals a family of 4 hibernation factors (SriA-SriD) in the archaeon Methanosarcina acetivorans, protecting ribosomes under stress for efficient dormancy. PMID:42350466, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74727-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Largest proteogenomic study (n=78,664) identifies >24,000 protein QTLs for 1,116 proteins, revealing genetic effects across pathways & cell types. Insightful advances! PMID:42097137, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00385-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Trial in NEJM: A 6-month regimen of bedaquiline, linezolid, delamanid & levofloxacin/clofazimine shows promise for rifampicin-resistant TB in South Africa for ages 6+. PMID:42341301, N Engl J Med 2026, @NEJM https://doi.org/10.1056/NEJMoa2503687 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New insights reveal the complex of BLTP VPS13A and scramblase XK, visualized by cryo-EM, enhances lipid transfer between organelles, crucial for cellular function. PMID:42285089, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Explore how the type III-D2 CRISPR-Cas system synthesizes dual messengers SAM-AMP & S… PMID:42342668, Nat Commun 2026, @NatureComms @OTSociety @NAR_Open https://doi.org/10.1038/s41467-026-74422-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A study links autoantibodies (AABs) to neurological symptoms in long COVID (LC), showing increased AABs against CNS and PNS proteins in affected individuals. PMID:42208499, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600509X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Mind-blowing! 🌟 14 groups, 2,080 DNA hexamers, 190 20-mer duplexes, 10μs each = 0.25P… PMID:42342657, Nat Commun 2026, @NatureComms @OTSociety @NAR_Open https://doi.org/10.1038/s41467-026-74390-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪