@sigtrans-sttt.bsky.socialRAC1 #SUMOylation emerges as a druggable regulator of #BreastCancer #Metastasis. Blocking this switch with TAT-PRASI reduces RAC1 activity and RAC1–POTEE interaction, impairing invadopodia formation and metastatic invasion. @usaloficial.bsky.social @ucm.es
#STTT #OpenAccess: doi.org/10.1038/s413...
@sigtrans-sttt.bsky.socialA multitarget strategy may help address #TNBC heterogeneity.
Opti-hTIF1γ suppresses β-catenin, TGFβ and STAT3 signaling while downregulating CD47 and CXCL5, enhancing #macrophage phagocytosis and #antitumoractivity.
#TumorMicroenvironment #CancerBiology
#STTT #OpenAccess: doi.org/10.1038/s413...
@sigtrans-sttt.bsky.socialThis study uncovers how polymeric #Alpha1Antitrypsin accumulation perturbs Paneth cell #Proteostasis via #ERstress and impaired lysosomal clearance, linking deficiency to severe intestinal inflammation.
@sigtrans-sttt.bsky.socialLearn how all-trans retinoic acid prevents CD8+ T-cell exhaustion and potentiates anti-PD-1 therapy in #Glioblastoma by activating WNT/β-catenin–TCF-1βBD signaling.
#STTT #OpenAccess: doi.org/10.1038/s413...
#CancerResearch #TranslationalMedicine
@sigtrans-sttt.bsky.socialHow does macrophage zinc accumulation worsen #MASLD progression?
Macrophage zinc trapping activates IRE1α–XBP1s signaling, promoting IL-1β-driven #MetabolicReprogramming and lipid transfer to hepatocytes, driving liver inflammation.
@sigtrans-sttt.bsky.socialQuiescent #BreastCancer stem-like cells can reawaken in #TNBC.
New study in #STTT identifies an ENO1–lactate–H4K12la feedback loop that upregulates PCNA to activate qsBCSCs, revealing a metabolic–epigenetic axis linked to tumor growth.
@sigtrans-sttt.bsky.socialThe anti-TFRC antibody PPMX-T003 suppresses #ColorectalCancer growth and metastatic colonization in preclinical models, highlighting iron-dependent tumor survival as a target for limiting metastatic progression.
#STTT #OpenAccess: doi.org/10.1038/s413...
#AntibodyTherapy #TargetedTherapy
@sigtrans-sttt.bsky.socialTraditional #Biomarker discovery suffers from single-modality analyses, weak mechanistic foundations, and low reproducibility.
This review examines #AI approaches for precision diagnostics and targeted therapies.
@sigtrans-sttt.bsky.socialHow can functional RNA molecules move beyond simple protein coding to power next-gen loss- and gain-of-function treatments? This review explores emerging druggable RNAs, optimization, and delivery systems for #clinicaltherapeutics.
@sigtrans-sttt.bsky.socialTKTL1-driven #Glycolysis increases lactate and promotes #Immunosuppressive dendritic-cell signaling in #HCC. Targeting the TKTL1–HIF-1α–HK2 axis and lactate reprograms the #TumorMicroenvironment to enhance PD-1 blockade.
@sigtrans-sttt.bsky.socialInotodiol activates LXRβ and promotes PPARδ-dependent #SIRT3 transcription, engaging the LXRβ/SIRT3/PGC-1α pathway to restore mitochondrial function and counter age-associated #MuscleWasting and #MetabolicDysfunction.
@sigtrans-sttt.bsky.socialHow do #Cuproptosis and #Ferroptosis intersect across disease?
This review connects metal metabolism, redox imbalance, organelle crosstalk, and regulatory networks with therapeutic strategies, #Biomarkers, and patient stratification.
#STTT #OpenAccess: doi.org/10.1038/s413...
#PrecisionOncology
@sigtrans-sttt.bsky.socialHow can targeting synthetic lethal interactions revolutionize #Cancer treatment?
This review examines PARP, ATR, ATM, DNA-PK, and emerging non-DDR targets, while addressing resistance, combination strategies, and patient selection. @uab.cat #Biomarkers
@sigtrans-sttt.bsky.socialADC development requires coordinated optimization of antigens, antibodies, linkers, and payloads. This review explores how AI and computational #Biophysics can guide rational design, patient stratification, #Pharmacokinetics, and dosing.#DrugDesign
@sigtrans-sttt.bsky.social#Cancer heterogeneity operates across interconnected biological scales. The HITET framework links them through niche–flow–feedback interactions to organize mechanisms, therapeutic strategies, and hypotheses for future validation.#CancerGenomics
@sigtrans-sttt.bsky.social#FractureRepair relies on coordinated immune, vascular, neural, and skeletal signaling. This review connects key mechanisms of #BoneHealing with targeted regenerative strategies and their translational challenges.
#STTT #OpenAccess: doi.org/10.1038/s413...
#MotorDysfunction #CellBiology
@sigtrans-sttt.bsky.socialCan precision retinoid therapy overcome therapeutic resistance?
This review defines “retinoid endotypes” shaped by metabolic niches, chromatin state, and #microenvironmental cues to inform patient stratification and precision therapy.
@sigtrans-sttt.bsky.socialUSP2 inhibition destabilizes STUB1 to suppress pathological #Pexophagy in PEX1-deficient models, restoring peroxisome abundance while mitigating metabolic abnormalities, neuro-axonal pathology, and motor dysfunction.
#STTT #OpenAccess: doi.org/10.1038/s413...
#Neurobiology #MolecularMedicine
@sigtrans-sttt.bsky.socialResearchers show that targeting BIRC6 disrupts a Treg-driven pathway that supports aged HSC survival, helping rebalance #hematopoiesis, reduce #Immunosenescence, and improve immune function in models of #Aging.
#STTT #OpenAccess: doi.org/10.1038/s413...
#Hematology #Immunology
@sigtrans-sttt.bsky.socialSingle-cell #Multiomics reveals that #TNBC-derived #Exosomes reshape T cells through regulatory and dysfunctional states, #miRNA-mediated immune suppression, and distinct γδ and αβ TCR clonotypic expansions.
