Polyploidy is a major evolutionary force in angiosperms, with 132 ancient WGD events analyzed across 470 species, revealing non-random clustering. Fascinating! PMID:42105759, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00397-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Precision medicine's potential hinges on top-tier genome sequencing. Address key challenges: germline, tumor, cell-free DNA, genetic therapy standards. PMID:42387168, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10621-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Colorectal cancer liver metastases show striking heterogeneity: 5-year survival is <44.2% for 'replacement' vs. 73.4% for 'encapsulated.' No therapies yet. PMID:42386979, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10686-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Exciting research: 34 circRNAs identified in blood for early Alzheimer's diagnosis. Predictive model matches plasma pTau217 effectiveness. PMID:42387213, Nat Med 2026, @NatureMedicine https://doi.org/10.1038/s41591-026-04485-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Malaria vaccine development struggles due to lack of T cell targets. Cross-stage, cross-species CD8⁺ T cell antigens identified for P. falciparum & P. vivax. PMID:42386975, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10730-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New study discovers 7 de novo EHMT2 variants causing autosomal dominant Kleefstra syndrome. These reduce G9a methyltransferase activity, revealing new genetic insights. PMID:42386776, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74987-w #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study finds restoring cortical disinhibition reduces Huntington's symptoms. In-depth 2-photon imaging reveals roles of neuronal subtypes. HD movement disorder unravelled. PMID:42386967, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10671-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Developed a CRISPR knockout mouse library targeting 84 host genes for in vivo influenza A studies, paving the way for better understanding of viral pathogenesis. PMID:42302780, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600591X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Targeted TFO liposome (tLipo-TFO1) reduces PAI-1, addressing pulmonary fibrosis by enhancing ECM clearance. PMID:42385711, Cell Rep Med 2026 https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(26)00326-5?rss=yes&utm_source=dlvr.it&utm_medium=twitter #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Metastasis in CRC is driven by tumor cell plasticity. TROP2, a marker linked to poor outcomes, associates with WNT^low and fetal-like states, fueling resistance. PMID:42386981, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10705-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

GLP-1 receptor agonists in hidradenitis suppurativa: study of mortality, CV events, and systemic complications in cohort. Discuss! 🔍 PMID:42384412, JAMA Dermatol 2026 https://doi.org/10.1001/jamadermatol.2026.1907 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study reveals change: 1 in 4 women, 1 in 100 men face military sexual trauma. Treatment up but suicidal thoughts persist. PMID:42160071, JAMA Psychiatry 2026, @JAMAPsych https://doi.org/10.1001/jamapsychiatry.2026.1203 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Casdatifan, a potent HIF-2α inhibitor, shows durable antitumor activity in refractory metastatic ccRCC per ARC-20 study (NCT05536141). Manageable safety. PMID:42386974, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10718-x #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

CANVAS leverages AI to decode tumor microenvironments from H&E histopathology, analyzing 18M+ cells to uncover spatial habitat dynamics influencing therapy response. PMID:42302781, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00590-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A genome-scale genetic interaction map in HAP1 cells reveals ~89,000 interactions, organizing genes into modules linked to protein complexes—key for targeted therapies! PMID:42049019, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00345-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Discovering new enzymes with metal-coordination mining could transform enzyme prediction, linking genome insights to real-world applications. PMID:42386972, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10716-z #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Hippocampal theta cycles sweep spatial paths, aiding navigation by directing behavior to goals. Theta sweeps are task-relevant for rapid planning. #NeuralDynamics PMID:42386948, Nat Neurosci 2026, @NatureNeuro @Cornell https://doi.org/10.1038/s41593-026-02364-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Transposable elements (TEs) make up nearly 50% of mammalian genomes, impacting gene expression, evolution, and disease through regulatory roles at individual loci. PMID:42276034, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00520-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New study reveals E3 ligase MARCH7 as a critical ferro-guardian, inhibiting ferroptosis by ubiquitylating NCOA4, regulating intracellular Fe²⁺ homeostasis. #Ferroptosis PMID:42049018, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00388-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Excessive mechanosensation via PIEZO1 in bladder epithelium leads to increased nociceptive innervation and chronic pain, linked to SLC7A11 and glutamate signaling. PMID:42361796, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00649-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪