L’ischemia degli arti nello shock con vasopressori viene spesso attribuita alla dose. Questa review rilegge la SPG come trombosi microvascolare tromboinfiammatoria, tipicamente con DIC e shock liver. #ProtectiveHemodynamics #CriticalCare
https://doi.org/10.1093/ehjcvp/pvag078

Ischemic limbs during vasopressor-treated shock are often blamed on drug dose. This review reframes SPG as thromboinflammatory microvascular thrombosis—typically with DIC and shock liver. #ProtectiveHemodynamics #CriticalCare
https://doi.org/10.1093/ehjcvp/pvag078

Dopo arresto cardiaco, l’ipercapnia lieve può migliorare ossigenazione cerebrale e marker emodinamici, ma senza benefici duraturi neurologici o di sopravvivenza. Migliore fisiologia non significa automaticamente migliore outcome. #CriticalCare
https://doi.org/10.1186/s40635-026-00974-6

Which of the following is the most likely diagnosis?

A. Acute ischemic thromboembolic stroke

B. Cerebral arterial vasospasm

C. Focal partial seizures

D. Posterior reversible encephalopathy syn.drome

#FOAMed #MedEd #CriticalCare #ICU #emimcc

Mild hypercapnia after cardiac arrest can improve cerebral oxygenation and some hemodynamic markers, yet trials have not shown durable neurologic or survival benefit. Better physiology is not automatically better outcome. #CriticalCare
https://doi.org/10.1186/s40635-026-00974-6

SODa-BIC ha corretto più rapidamente l’acidosi, ma senza ridurre eventi renali maggiori, mortalità o RRT rispetto al placebo. Correggere il pH è un successo biochimico; il trial chiede se questo migliori il paziente. #CriticalCare
https://doi.org/10.1056/NEJMe2610218

SODa-BIC corrected acidosis faster, but did not reduce major adverse kidney events, mortality or RRT versus placebo. Correcting pH is a biochemical success; the trial asks whether the patient benefits from it. #CriticalCare
https://doi.org/10.1056/NEJMe2610218

A privilege to present with our MDT at today’s Critical Care Peer Review—my first as Clinical Director. Proud of our team’s preparation, collaboration & commitment to improving care. #CriticalCare #Team

Should you give sodium bicarbonate for metabolic acidosis in the ICU? 🧪

Physiologically, it makes sense. However, a systematic review of 5 randomized controlled trials in critically ill patients reveals a more nuanced picture.

#CriticalCare #MetabolicAcidosis #MedEd #FOAMEd

🚨1 de cada 5 muertes a nivel mundial está vinculada a la sepsis.

#WorldSepsisDay #DíaMundialDeLaSepsis
#InvestInSepsis #invierteensepsis
#StopSepsis #SaveLives #SepsisResearch #GlobalHealth #CriticalCare #SaludPública #EvidenceBasedMedicine #ODS3 #revistaenfermeríauniversitaria

Does sodium bicarbonate improve outcomes in severe metabolic #acidosis? 🧪

Dr Bram Rochwerg discusses the recent meta-analysis, Surviving Sepsis Campaign guidance & benefits in AKI patients: mcmastertextbook.one/en/knowledge...

#CriticalCare #Bicarbonate #McMasterPerspective #MedEd #FOAMEd

Il comparatore conta: lo studio chiede quando, non se, aggiungere vasopressina dopo noradrenalina ≥0,25 μg/kg/min. In 3.810 pazienti, 0–3 h era associato a −5 punti di mortalità a 28 giorni vs 3–6 h. Un segnale sul timing, non un mandato RCT. #CriticalCare
https://doi.org/10.1007/s00134-026-08575-3

The comparator matters: this study asks when—not whether—to add vasopressin once norepinephrine reaches ≥0.25 μg/kg/min. In 3,810 patients, 0–3 h was associated with 5% lower 28-day mortality than 3–6 h. A timing signal, not an RCT mandate. #CriticalCare
https://doi.org/10.1007/s00134-026-08575-3

Volunteers like Matt strengthen NHS emergency teams and save lives.

#CriticalCare #volunteering #healthcare

India: 631 Critical Care Blocks sanctioned nationwide; 10 opened this week. ICU capacity is more than beds: oxygen, diagnostics and trained staff must follow. #CriticalCare
Source: Press Information Bureau
https://www.pib.gov.in/newsite/erelcontent.aspx?relid=294604&reg=48&lang=2

Sette RCT, 2.408 pazienti: la rianimazione guidata dalla perfusione periferica ha dato RR 0,87 sulla mortalità a 28 giorni (P=0,06), ma una probabilità bayesiana di beneficio del 97,2%. Stessi dati, diversa grammatica dell’incertezza. #CriticalCare
https://doi.org/10.1097/CCM.0000000000007364

Seven RCTs, 2,408 patients: peripheral perfusion-guided resuscitation gave RR 0.87 for 28-day mortality (P=.06), yet a 97.2% Bayesian probability of benefit. Same data, different grammar of uncertainty. #CriticalCare
https://doi.org/10.1097/CCM.0000000000007364