(BioRxiv All) Pulsed-SILAC in single mouse embryos reveals early embryonic protein synthesis dynamics and phosphosite regulation: Early embryogenesis relies extensively on maternally deposited products until zygotic genome activation, yet the dynamics for the synthesis of new… #BioRxiv #MassSpecRSS

(BioRxiv All) Relative humidity differentially modulates decay of structurally distinct respiratory viruses in deposited human saliva particles: Respiratory viruses pose a major threat to human health. Environmental virus persistence in respiratory secretions is essential for… #BioRxiv #MassSpecRSS

(BioRxiv All) Removing an S-layer enables endolysin-derived probes to detect Paenibacillus thiaminolyticus in mixed bacterial populations: The emerging neonatal bacterial pathogen Paenibacillus thiaminolyticus causes sepsis and postinfectious hydrocephalus, yet few tools are… #BioRxiv #MassSpecRSS

(BioRxiv All) Volatile Metabolic Signatures Reveal Early Pulmonary Responses to PFAS Exposure: Inhalation of airborne per- and polyfluoroalkyl substances (PFAS) represents an important yet understudied exposure route. While volatile organic compounds (VOCs) have been widely… #BioRxiv #MassSpecRSS

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(BioRxiv All) A microbiome-derived metabolite from Staphylococcus epidermidis inhibits Staphylococcus aureus biofilm formation and virulence: Staphylococcus epidermidis is a common member of the healthy skin microbiome that contributes to barrier function and protection… #BioRxiv #MassSpecRSS

(BioRxiv All) Comprehensive analysis of ammonia and biogenic amines in ecologically diverse systems with high-resolution mass spectrometry: The acquisition of sufficient nitrogen for growth, as well as the disposal of highly toxic nitrogen-containing degradation products,… #BioRxiv #MassSpecRSS

(BioRxiv All) Toward a global chemogeography of dissolved organic matter: a molecular trait dataset across Earth systems: Dissolved organic matter (DOM) is a central component of biogeochemical cycling, but molecular observations generated by ultrahigh-resolution mass… #BioRxiv #MassSpecRSS

(BioRxiv All) Tracking cellular biomolecular condensate dynamics under proteostatic stress with middle-down phosphoproteomics: Coordination of biological function requires the partition of cellular components including into biomolecular condensates, but an overall landscape of… #BioRxiv #MassSpecRSS

(BioRxiv All) The scents of summer: Plant-diversity and vegetation-height drive health-relevant scent exposure in urban greenspaces: Urban green infrastructure is increasingly promoted as a public-health intervention, yet the biological features that determine exposure to… #BioRxiv #MassSpecRSS

(BioRxiv All) RNF25 Ubiquitin E3 activity Safeguards Genome Integrity by Modulating DNA Replication, Transcription and Translation.: The human genome encodes several hundreds of ubiquitin E3 enzymes, most of which have poorly understood biological roles. In search for novel… #BioRxiv #MassSpecRSS

(BioRxiv All) Metabolomics highlights cardiovascular risk factor links to sphingolipid and one-carbon metabolism in asymptomatic adults: Background: Metabolic perturbations associated with cardiovascular disease (CVD) risk factors prior to clinical disease manifestation may… #BioRxiv #MassSpecRSS

(BioRxiv All) A dependency-free, streamable format and cross-language toolkit for scalable LC-MS feature detection: reading only what you need: Mass spectrometry generates data faster than it can be read, and the exchange standard, mzML, is text-based and must be parsed in… #BioRxiv #MassSpecRSS

(BioRxiv All) H2A.Z-H2B.V nucleosomes form a specialised scaffold for transcription initiation in Trypanosoma brucei: Regions of transcription initiation are often enriched in the histone variant H2A.Z. This is especially true in the divergent eukaryote Trypanosoma brucei,… #BioRxiv #MassSpecRSS

(BioRxiv All) Neuroblastoma-derived small extracellular vesicles retaincellular identity and adrenergic/mesenchymal state signatures: Neuroblastoma is a heterogeneous pediatric malignancy characterized by distinct genomic subgroups and cell-state plasticity between adrenergic… #BioRxiv #MassSpecRSS

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(BioRxiv All) PREpiBind: Protein Representation-integrated Epitope--MHC Class II Binding Prediction: Accurate prediction of peptide-MHC class II (pMHC-II) binding remains challenging because of extensive MHC polymorphism and context-dependent peptide recognition, and it is… #BioRxiv #MassSpecRSS

(BioRxiv All) ProtPipe2: Multi-Platform Downstream Proteomics Analysis Tool: Proteomics studies increasingly use different technologies, including mass spectrometry, the antibody-based Olink platform, and the aptamer-based SomaScan platform. However, downstream analysis often… #BioRxiv #MassSpecRSS

(BioRxiv All) MALDI-TOF imaging mass spectrometry demonstrates sex- and age-dependent spatial changes in brain energy metabolism in response to amyloid stress using a mouse model of Alzheimers Disease: Alzheimer's disease (AD) is the most common form of dementia, and no… #BioRxiv #MassSpecRSS

(BioRxiv All) The coculture of Fomitopsis betulina with Escherichia coli induces a nutritional stress and triggers secondary metabolism pathways.: Basidiomycete fungi are an underexplored source of specialized metabolites with significant biotechnological potential. However,… #BioRxiv #MassSpecRSS