Study identifies >1,000 somatic variants in 311 AD brain samples, linking cancer driver genes, clonal hematopoiesis, and neuroinflammation via microglia-like cells. PMID:42019491, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00341-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Thank you @shihcheng.bsky.social for sharing this elegant study, fusing Ca²⁺ imaging, morphology & in situ transcriptomics for 30 neurons.
We are pleased to find and highlight research like this.
Follow @academaxjournals.bsky.social for similar #STEM studies.

#MedEdsky #RNA #ASHG #ESHG

#OnThisDay in 1985, Frisco and Robert planned Frisco’s story, and Robert filled Anna in after bringing her and Robin home #RnA #FnF #ClassicGH #GH #GeneralHospital

A novel trimodal platform integrates in vivo Ca²⁺ imaging, detailed neuron morphology, and in situ transcriptomics, linking neuronal activity to function for 30 neurons. PMID:42314668, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00641-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A comprehensive study of 470 angiosperm species reveals 132 ancient WGD events cluster non-randomly, highlighting polyploidy as a major evolutionary driver amid environmental upheaval. PMID:42105759, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00397-1 #Medsky #Pharmsky #RNA 🧪

A genetic variant, rs17437411, linked to lowered blood counts and cancer protection disrupts the lncRNA HOXA opposi, highlighting its role in regulating hematopoietic stem cells. PMID:42068976, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00439-3 #Medsky #Pharmsky #RNA #ASHG 🧪

New research reveals 2 clades of SARS-CoV-2-related coronaviruses in Thai horseshoe bats, one of which binds human ACE2, highlighting potential zoonotic risks. PMID:42097139, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600454X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Cryo-EM reveals VPS13A's complex with XK in lipid transfer, highlighting its role in bridging membranes at contact sites with hydrophobic channels for efficient lipid delivery. PMID:42285089, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6 #Medsky #Pharmsky #RNA #ASHG 🧪

🧬 RNA m5C in cancer: ready for the clinic? 📷 Key insights: assay limitations, reliable quantification & a roadmap to clinical valid🎯 #RNA #CancerBiomarkers

www.sciencedirect.com/science/arti...

🧬 Antibodies meet programmable nucleic acids.
A new #LabMedDiscovery review explores antibody–oligonucleotide conjugates (AOCs)—
🔬 One platform, bridging diagnostics and therapeutics
www.sciencedirect.com/science/arti...

#AOC #LaboratoryMedicine #MultiOmics #RNA #Diagnostics

In small-cell lung cancer, excessive vascular integrity limits anti-tumor immunity, creating immune deserts. Wang et al. propose "reverse normalization" to enhance immune access and combat immunotherapy… PMID:42349379, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00634-3 #RNA 🧪

Study reveals "cross-language neurons" in human hippocampus, responding to similar words (e.g., "tierra" & "earth"). Key insight: semantic tuning bridges bilingualism! 🧠✨ PMID:42341760, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00579-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study reveals how eIF2B's allosteric disordering controls ISR by shifting eIF2's role from substrate to inhibitor under stress. PMID:42373951, Nat Chem Biol 2026, @nchembio https://doi.org/10.1038/s41589-026-02256-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New study reveals TRPC4/5 channels key to tFUS effects in mice's retrosplenial cortex, reducing sensitivity and activating early growth response. Exciting progress! PMID:42373633, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74779-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Nur77 boosts NK cells against hepatocellular carcinoma by improving penetration and overcoming immunosuppression. Key role identified via spatial and single-cell transcriptomics. PMID:42374019, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-75027-3 #Medsky #Pharmsky #RNA #ASHG 🧪

Engineered GMPs can now expand long-term while maintaining myeloid potential, overcoming challenges in tumor immunotherapy. Myeloperoxidase plays a key role in this proliferation, establishing GMPs as a… PMID:42320470, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00643-4 #RNA 🧪

Cisplatin, while effective for cancer, triggers neuronal death via nucleotide excision repair (NER). Unlike in dividing cells, NER in neurons enhances vulnerability to damage. PMID:42269607, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00584-2 #Medsky #Pharmsky #RNA #ASHG 🧪

A study of 1,025 species reveals that early genomes were random, evolving into organized "global folding" and "checkerboard" architectures in plants, shaping spatial regulation. PMID:42019492, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00343-0 #Medsky #Pharmsky #RNA #ASHG 🧪

~50% of fertilized human eggs arrest in pre-implantation. Key findings show 2nd mitotic divisions are error-prone; centriole overduplication can be suppressed by PLK4 inhib. PMID:42276044, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00637-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Zebrafish study reveals oligodendrocytes use Gephyrin to myelinate GABAergic axons, regulating myelin sheath growth. Key insights into neuron circuit tuning! PMID:42373637, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74902-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪