Interspecies blastocyst complementation offers hope for organ shortages, but host macrophages hinder xenogeneic cell engraftment via xenophagocytosis. Elevated phosphatidylserine on these cells acts as an… PMID:42248141, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00575-1

Surface immune signaling activates NLR receptors via mRNA splicing; reveals mechanism in potato Rpi-vnt1 protein, impacting PTI/ETI coordination. PMID:42391383, Science 2026, @ScienceMagazine https://doi.org/10.1126/science.adx9929 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

2'3'-cGAMP triggers membrane shearing in bacteria, enhancing broad phage immunity via cyclic-oligonucleotide-based signaling. Key TM proteins reveal novel antiviral mechanisms. PMID:41999741, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00344-2 #Medsky #Pharmsky #RNA #ASHG 🧪

New findings reveal that allergens trigger PAR1-dependent ferritinophagy in lung epithelial cells, increasing labile Fe²⁺, which activates GSDMD independently of proteases, driving IL-33 release and airway… PMID:42361797, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00653-7

CRISPR-driven TAPIR boosts rRNA transcription by inducing 47S rDNA, enlarging nucleoli … PMID:42391322, Science 2026, @ScienceMagazine @OTSociety @NAR_Open https://doi.org/10.1126/science.aeh1348 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A phytoscreen of 43 fruits/veg revealed garlic as a potent insect behavior manipulator. Diallyl disulfide deters mating & egg-laying in Drosophila & mosquitoes! PMID:41999745, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00338-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Polyploidy is key in angiosperm evolution. Analyzing 470 species revealed 132 ancient WGD events cluster non-randomly, suggesting environmental upheaval drives polyploidy. PMID:42105759, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00397-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A new deep learning framework predicts genetic ancestry with high accuracy across diverse populations, promoting fairness in genomics. #GenomicAI PMID:42392034, Am J Hum Genet 2026, @AJHGNews https://www.cell.com/ajhg/fulltext/S0002-9297(26)00229-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Cisplatin triggers neuronal death via NER, which paradoxically harms neurons unlike in dividing cells, highlighting the need for better neuroprotective strategies. PMID:42269607, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00584-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

ETBF rewires host metabolism via its virulence factor, Bacteroides fragilis toxin, fueling oxidative growth in the inflamed gut, critical for disease progression. PMID:42066751, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00401-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New insights into lipid transfer reveal that VPS13A, a bridge-like lipid-transfer protein, forms a complex with the scramblase XK, facilitating organelle communication. PMID:42285089, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Promising phase 1 trial of CAR T cell therapy in recurrent GBM (NCT05168423) showed tumor reduction & survival extension, yet relapses persist. Key findings emphasize the vital role of the immune response in… PMID:42296961, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00585-4

Engineered macrophages show promise for tumor immunotherapy; however, ex vivo expansion has been limited. A study establishes conditions for long-term expansion of granulocyte-monocyte progenitors (GMPs) while… PMID:42320470, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00643-4

Excessive sensory response via PIEZO1 in bladder epithelial cells can drive chronic pain from uropathogenic E. coli infection, revealing a critical link with IL-6 signaling. PMID:42361796, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00649-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New findings reveal that parvalbumin-expressing neurons in the basal forebrain enhance sustained attention by disinhibiting cortical pathways, challenging prior beliefs about cholinergic neurons. PMID:42349384, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600646X #Medsky #Pharmsky 🧪

Explore variability among 218 metabolic enzymes across single cells using imaging-based proteomics—uncover non-genetic diversity impacting drug resistance and immune response. 🚀 PMID:42393051, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74172-z #Medsky #Pharmsky #RNA #ASHG 🧪

VPS13C/PARK23, a lipid transport protein, is crucial for lysosome repair. It binds lysosomes under stress, triggering repair via major membrane alterations. PMID:42393076, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-75145-y #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

GWAS found 17 variants linked to gastric cancer. Analyzed 262 gastric tissues for eQTLs, sQTLs, & apaQTLs, integrating data from 10,254 cases. Key genes emerge! #GastricCancerGenetics PMID:42392035, Am J Hum Genet 2026, @AJHGNews https://www.cell.com/ajhg/fulltext/S0002-9297(26)00228-4 #Medsky 🧪

A model reveals the mammalian cortical connectome's intricate topology, shaped by physical constraints and unique regional connectivity profiles. Fascinating insights! PMID:42361798, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00648-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Explore a vast 14M cell dataset from 47 tissues, revealing 379 hormone/receptor interactions. Discover novel hormone sites! PMID:42207862, Science 2026, @ScienceMagazine https://doi.org/10.1126/science.aeb2672 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪