(BioRxiv All) A dependency-free, streamable format and cross-language toolkit for scalable LC-MS feature detection: reading only what you need: Mass spectrometry generates data faster than it can be read, and the exchange standard, mzML, is text-based and must be parsed in… #BioRxiv #MassSpecRSS

(ACA) Synergistic CID and EAD Fragmentation by High-Resolution Mass Spectrometry for Rapid Discovery and De Novo Structural Deduction of a New Peptide: Publication date: Available online 21 September 2026

Source: Analytica Chimica Acta

Author(s): Junxiao Wang, Chang Wang,… #AChimActa #MassSpecRSS

(BioRxiv All) H2A.Z-H2B.V nucleosomes form a specialised scaffold for transcription initiation in Trypanosoma brucei: Regions of transcription initiation are often enriched in the histone variant H2A.Z. This is especially true in the divergent eukaryote Trypanosoma brucei,… #BioRxiv #MassSpecRSS

(BioRxiv All) Neuroblastoma-derived small extracellular vesicles retaincellular identity and adrenergic/mesenchymal state signatures: Neuroblastoma is a heterogeneous pediatric malignancy characterized by distinct genomic subgroups and cell-state plasticity between adrenergic… #BioRxiv #MassSpecRSS

Fast method for assessing binder migration in lithium-ion battery electrodes using glow discharge-sector field-mass spectrometry #nature #MassSpecRSS

(EJMS) Analysis of multiply charged monomer and dimer ions of the amyloid β(1–28) peptide using electrospray ionization mass spectrometry and collision-induced dissociation: European Journal of Mass Spectrometry, Ahead of Print.
Tandem mass spectrometry (MS) fragmentation… #EJMS #MassSpecRSS

(ChemRxiv) Hypervelocity impact mass spectrometry enables membrane phospholipid detection in ocean-world plumes: Saturn's ocean moon Enceladus and Jupiter's moon Europa expel subsurface material into space, enabling direct sampling of potentially habitable ocean environments without… #MassSpecRSS

Author Correction: A longitudinal cohort study uncovers plasma protein biomarkers predating clinical onset and treatment response of rheumatoid arthritis #nature #MassSpecRSS

(Biomed Chrom) UHPLC‐MS/MS–Based Simultaneous Quantification and Pharmacokinetic Characterization of 20 Components of Xiangju Rupining Capsule in Rats: ABSTRACT

Xiangju Rupining Capsule (XJRPN) is a Chinese patent medicine clinically used for the treatment of mammary… #massSpecRSS #biomedchrom

(A Chem) Strong Hydration
and Salt Association Complicate Nucleotide
Oligomer Analysis by Mass Spectrometry: AbstractThe abiotic synthesis of nucleotide oligomers via wet–dry
cycling may have provided a source of nucleic acids necessary for
the origin of primitive forms of life. Mass… #MassSpecRSS

(A Chem) Rapid Species-Level
Classification of Urinary Pathogens
from Raw LC-MS/MS Signals Using Machine Learning: AbstractUrinary tract infections
are among the most common infections
in
humans, yet their diagnosis still depends on time-consuming workflows
based on microbial culture,… #MassSpecRSS

(RCM) Preparation of Deuterium‐Labeled Tadalafil and Omeprazole by Carbon Hydrogen–Deuterium Exchange: Hydrogen Scrambling, Acid‐Induced Transformation, and LC‐MS Applications: ABSTRACT

Rationale

Stable isotope-labeled compounds are indispensable… #RapidCommunMassSpectrom #MassSpecRSS

(BioRxiv All) PREpiBind: Protein Representation-integrated Epitope--MHC Class II Binding Prediction: Accurate prediction of peptide-MHC class II (pMHC-II) binding remains challenging because of extensive MHC polymorphism and context-dependent peptide recognition, and it is… #BioRxiv #MassSpecRSS

(BioRxiv All) ProtPipe2: Multi-Platform Downstream Proteomics Analysis Tool: Proteomics studies increasingly use different technologies, including mass spectrometry, the antibody-based Olink platform, and the aptamer-based SomaScan platform. However, downstream analysis often… #BioRxiv #MassSpecRSS

(BioRxiv All) MALDI-TOF imaging mass spectrometry demonstrates sex- and age-dependent spatial changes in brain energy metabolism in response to amyloid stress using a mouse model of Alzheimers Disease: Alzheimer's disease (AD) is the most common form of dementia, and no… #BioRxiv #MassSpecRSS

(Nature) Tissue expansion mass spectrometry imaging (TEMI) for high-spatial-resolution multiomics molecular mapping #MassSpecRSS

Tissue expansion mass spectrometry imaging (TEMI) for high-spatial-resolution multiomics molecular mapping #nature #MassSpecRSS

(JPR) Prioritizing
Peptides for Targeted Mass Spectrometry
Experiments Using Deep Learning: AbstractOne critical step in any targeted mass spectrometry experiment
is selecting, from each protein of interest, a small number of peptides
that respond well in the mass spectrometer and can… #MassSpecRSS

(Angew Chem) Methane Activation by B5+ Toward a CB5H2+ Isomer Containing a Planar Tetracoordinate Carbon Atom: Methane activation by B5
+ yields CB5H2
+ through H2 elimination. Electronic-structure calculations connect the nascent dehydrogenation product to a low-lying… (RSS) #AngewChem #MassSpecRSS

(JASMS) A Streamlined One-Pot
Extraction Method Enables High-Sensitivity
Top-Down Proteomic Characterization of Phospholamban from Biopsy-Scale
Cardiac Tissue: AbstractTop-down
proteomics (TDP) enables comprehensive characterization
of intact proteoforms, but the analysis of… (RSS) #MassSpecRSS