Transcriptional networks underlying tumour plasticity in small-cell lung cancer #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.09.26.754526v1

Distinct transcriptomic patterns in bicuspid aortic valve aortopathy suggest a unique mechanism of ascending aortic aneurysm progression #SingleCell 🧪🧬🖥️
https://www.researchsquare.com/article/rs-9696748/latest

Adaptive brain rewiring after brain injury via adult neurogenesis #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.09.22.753668v1

Discrete Morse Graph Construction for High-Dimensional Transcriptomic Data #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.09.22.753642v1

Luxar: Gaussian splatting for microscopy and scalable interactive web visualisation of multidimensional scientific data #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.09.22.753676v1

ctDNA Release Heterogeneity in Luminal Breast Cancer Revealed by Single-Cell Multi-Omics Spatial Analysis #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.09.27.754855v1

Learn how we used Droplet Paired-Tag to assess RNA expression and histone modifications in brain cells and PBMCs to identify novel cell-type-specific CREs and heritability factors linked to Alzheimer's

#Epigenetics #SingleCell #PairedTag #Multiomics #Alzheimers

u.epigenome.us/I8R4vBn2

Therapeutic Potential of iPSC-Derived TH+FOXA2+ Neuronal Extracellular Vesicles in Parkinson's Disease Revealed by Organoid and Rodent Models #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.09.22.753408v1

Single Cell Cytometry of Mouse Brain Tissue #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.09.22.753505v1

AtlasOT - The Fused Unbalanced Gromov-Wasserstein for Multimodal Integration of Disease Atlases #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.09.22.753496v1

Trustworthy super-resolution reconstruction across spatial omics modalities #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.09.25.754471v1

A framework for designing splice-junction experiments in deep 3' single-cell RNA sequencing #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.09.22.753522v1

YAP/TAZ-controlled ERK dynamics coordinate progenitor expansion and differentiation commitment #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.09.24.753950v1

β2 Integrins Differentially Regulate Macrophage Polarization, Inflammatory Signaling, and Function: A Prominent Role for CD11d #SingleCell 🧪🧬🖥️
https://www.researchsquare.com/article/rs-11007877/latest

Developed with input from @c-spirit.org & PCA, The BAR Single Cell Data Portal is now in beta, feat. curated scRNA-seq datasets, interactive data exploration, & the new SUPeR Viewer!

Explore the portal: bar.utoronto.ca/single_cell_...

#SingleCell #PlantScience

Biosynthetic Olfactory System from Multiplexed Engineered Microbes (BOSMEM) #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.09.25.753839v1

Disruption of the ARID1A-containing SWI/SNF complex reprograms tumor-associated macrophages and enhances immunotherapy response #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.09.25.754528v1

Dual-color fluorescent reporters resolve Alu and LINE-1 retrotransposition in single cells #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.09.26.754642v1

Metformin restores marrow mesenchymal lineage homeostasis in glucocorticoid-induced osteoporosis through a gut microbiota–butyrate–ERK1/2 axis #SingleCell 🧪🧬🖥️
https://www.researchsquare.com/article/rs-10742700/latest

Integrative Functional Genomics Identifies Candidate Brain and Pituitary Regulatory Mechanisms of Reproductive Aging #SingleCell 🧪🧬🖥️
https://www.researchsquare.com/article/rs-11157515/latest