Promising results in DMD treatment: LEAPER 2.0 uses circular ADAR-recruiting RNAs for effective exon skipping in monkeys & humans, reversing muscle degeneration. PMID:42269605, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00589-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

CANVAS reveals tumor ecosystems via AI, leveraging 18M+ cells from H&E histopathology, enhancing understanding of TME's role in disease progression. PMID:42302781, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00590-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

CD8+ T cells use cysteine for GSH production, enhancing effector functions, and for sulfur in FeS cluster synthesis via NFS1, crucial for proliferation. NFS1 deletion leads to T cell exhaustion. PMID:41923640, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00279-5 #Medsky #RNA 🧪

Histone H2A variants shape epigenomic patterns in Arabidopsis through antagonistic effects, forming heterochromatin without relying on RdDM by establishing H3K9me and non-CpG methylation. PMID:42380212, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74770-x #Medsky #Pharmsky #RNA 🧪

A study reveals a blood-brain barrier-like vascular gate (BVG) in small cell lung cancer (SCLC) that restricts immune cell infiltration, explaining low immunotherapy efficacy. PMID:42102817, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00452-6 #Medsky #Pharmsky #RNA #ASHG 🧪

Deep-Phase leverages neural networks to analyze microscopy images, revealing how drug-induced changes affect biomolecular condensate morphology, enhancing understanding of cellular organization. PMID:42242225, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00569-6 #Medsky #RNA 🧪

A 10-year study on 1,513 CRKP isolates reveals a dominant ST11-KL64 sublineage with enhanced invasiveness from genome data spanning 60,724 Klebsiella pneumoniae. PMID:42373658, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74832-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Wang et al. unveil RegVelo, a groundbreaking framework that combines gene regulatory networks with RNA velocity, pinpointing key regulators shaping cell fate changes! PMID:42276033, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600588X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Discovering high-confidence effector genes in osteoarthritis: Transcriptome analysis of 261 low-grade and diseased tissues from knee osteoarthritis patients reveals crucial insights! PMID:42373672, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74993-y #Medsky #Pharmsky #RNA 🧪

Groundbreaking study reveals a co-culture system of ESCs with extra-embryonic cells, mimicking primitive streak formation—a key to understanding human gastrulation! PMID:42341759, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00645-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New insights on cuproptosis reveal that CD8+ T cells boost tumor susceptibility to copper-dependent cell death, enhancing immunotherapy responses. Key findings show that cuproptotic cells trigger immune… PMID:42330950, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00636-7 #RNA 🧪

📽️ G&D Tapes 📽️

G&D Authors, Jeongjin Kim & Amit Behera, tell us about how they used CRASP-seq to identify RBM39 as a splicing regulator controlling IRE1α–XBP1 signaling in an adaptive response to proteotoxic stress.

Read the full story:
➡️ https://genesdev.cshlp.org/content/40/17-18/1448.full

#RNA

LEAPER 3.0 revolutionizes RNA editing by harnessing endogenous ADAR with engineered arRNAs, paving the way for precise edits via AlphaFold 3 structure insights. PMID:42269608, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00514-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Mendelian randomization reveals causal ties between risk factors & disease progression. Index event bias impacts analyses significantly. #Epidemiology PMID:42372731, Am J Hum Genet 2026, @AJHGNews https://www.cell.com/ajhg/fulltext/S0002-9297(26)00230-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A 2014 CCR5 frameshift signal was retracted after replication showed it was a splicing artefact from the old reporter, not real biology. #CCR5 #frameshift #retraction #RNA

https://freegardner.com/sci_scout/ccr5-frameshift-signal-questioned-by-retraction.html

October 2, 2026
👉 What if a single therapeutic strategy could target thousands of genetic diseases?
🙂 Another encouraging news story from Groupe UIG.
Read: lnkd.in/gtE5WvYr
#ARN #RNA #tRNA #GeneticMedicine #GeneticDiseases

ETBF rewires host metabolism using Bacteroides fragilis toxin to thrive in the inflamed gut, fueling oxidative growth and contributing to colitis and colorectal cancer. PMID:42066751, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00401-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

2 octobre 2026
👉 Et si une même stratégie thérapeutique pouvait s’attaquer à des milliers de maladies génétiques?
🙂 Une autre nouvelle encourageante du Groupe UIG.
Lire: www.utoronto.ca/news/rna-bre...
#ARN #RNA #tRNA #GeneticMedicine #GeneticDiseases

Transposable elements (TEs) make up nearly 50% of mammalian genomes, influencing gene expression and disease through their DNA and RNA forms, despite mostly losing mobility. PMID:42276034, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00520-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

(2/2) Arg and Lys promote condensation more readily than simpler cationic amino acids, highlighting how amino acid chemistry may have shaped early RNA–peptide organization.
#OriginOfLife #RNA #Ribosome
doi.org/10.64898/202...