@sigtrans-sttt.bsky.socialHow do gasdermin proteins execute inflammatory #CellDeath and drive disease pathology?
Insights into their activation, membrane pore formation, cell-death crosstalk, and context-dependent roles in #Inflammation, infection, and #Cancer.
@sigtrans-sttt.bsky.socialWhat drives #VascularCalcification beyond mineral deposition?
This review explores VSMC remodeling, #EndMT, cellular stress, and RUNX2-centered signaling crosstalk while assessing emerging therapeutic strategies.
@sigtrans-sttt.bsky.socialCan hyperactive #DNArepair be targeted in #Neuroendocrine #CervicalCarcinoma?
#Multiomics reveals HRR activation and a CAF–IL6–E2F1–BLM axis that limits #PARP inhibitor sensitivity, supporting dual PARP–BLM inhibition.
@sigtrans-sttt.bsky.socialLoss of βPIX in alveolar type 2 cells impairs stemness through reduced Wnt/β-catenin signaling, promoting transitional senescent progenitors and #Myofibroblast activation that drive spontaneous #PulmonaryFibrosis.
@sigtrans-sttt.bsky.socialA safer VSV-based intranasal #H5N1 #Vaccine elicits robust and durable humoral and mucosal immunity, with the optimized vector protecting against lethal viral challenge and supporting its potential for #AvianInfluenza prevention.
@sigtrans-sttt.bsky.socialThe melanoma-enriched noncanonical antigen EVA003 is endogenously presented on HLA-A*03:01 and recognized by a naturally occurring T cell receptor that, when transferred into T cells, enables antigen-dependent #Melanoma cell killing.
@sigtrans-sttt.bsky.socialHow durable is immunity after an XBB.1.5 booster? This longitudinal study tracks neutralizing antibody responses after trivalent XBB.1.5 #Vaccination, examining their magnitude, breadth, durability, and evolution against #SARSCoV2 variants.
#STTT #OpenAccess: doi.org/10.1038/s413...
#ImmuneEvasion
@sigtrans-sttt.bsky.social#CARTCellTherapy is moving beyond #Cancer.
This review explores its potential across #Autoimmune, aging-related, and #InfectiousDiseases, focusing on targeted cell depletion, immune remodeling, clinical advances, and translational challenges.
@sigtrans-sttt.bsky.socialHow do signaling networks guide #CellDifferentiation in health and disease?
This review explores Wnt, Notch, Hedgehog, TGF-β, and Hippo pathways, their regulatory crosstalk, disease roles, and potential for targeted therapies.
#STTT #OpenAccess: doi.org/10.1038/s413...
@sigtrans-sttt.bsky.socialResearchers uncover an HPGDS–PGD2 pathway that promotes pathogenic Th17 differentiation by antagonizing PPARγ, while HPGDS inhibition suppresses Th17 responses and alleviates #Autoimmune pathology in #MultipleSclerosis models.
@sigtrans-sttt.bsky.socialA phase I trial evaluates CNSI-Fe, a carbon #Nanoparticle–Fe(II) complex that delivers Fe iron directly into tumors to trigger #Cancer cell #Ferroptosis, showing a favorable safety profile and preliminary antitumor activity.
@sigtrans-sttt.bsky.social
@sigtrans-sttt.bsky.socialCan gingiva-derived MSCs (GMSCs) help preserve β-cell function in #Type1Diabetes (#T1DM)? A phase 1 trial links GMSC therapy to improved residual β-cell function, potentially through CD8+ T-cell exhaustion.
#STTT #OpenAccess: doi.org/10.1038/s413...
#CellTherapy #BetaCellFunction
@sigtrans-sttt.bsky.socialInfection and hypoxic stress converge on the PHD1–TRIM21–CDC20 axis, promoting CDC20 degradation and securin and MCL1 accumulation to drive cancer cell #Aneuploidy and #Chemoresistance.
#STTT #OpenAccess: doi.org/10.1038/s413...
@sigtrans-sttt.bsky.socialCDK12/13 inhibition exposes a vulnerability in platinum-resistant #OvarianCancer by disrupting transcription and #AlternativeSplicing, with the CDK12–SFPQ/p54nrb complex driving RNA-processing reprogramming and cytotoxicity.
@sigtrans-sttt.bsky.socialMuscle cells retain intrinsic #miRNA alterations in #Type2Diabetes. T2D-derived myoblasts show altered miRNA expression and sEV secretion linked to metabolic pathways, while their sEVs fail to enhance adipocyte metabolic function. @harvardmed.bsky.social
@sigtrans-sttt.bsky.socialMycobacterium abscessus directly links the #TumorMicrobiome to #NSCLC mutagenesis, as bacterial NDK phosphorylates IRF3 to amplify interferon signaling and sustain #APOBEC3A-driven genomic diversification.
#STTT #OpenAccess: doi.org/10.1038/s413...
@sigtrans-sttt.bsky.socialThe phase 3 ANCHOR trial finds that anlotinib + CapeOX shows similar antitumor activity to bevacizumab + CapeOX in RAS/BRAF wild-type #Metastatic #ColorectalCancer, but does not meet the prespecified noninferiority margin for PFS.
@sigtrans-sttt.bsky.socialThe phase 3 ICWIP #ClinicalTrial shows that three-year adjuvant icotinib following #Chemotherapy significantly improves disease-free survival versus placebo in completely resected stage II–IIIA disease, with a manageable safety profile.
@sigtrans-sttt.bsky.socialmiR-150 fine-tunes stem cell fate through dual control of #SOX2, regulating its mRNA stability and #Autophagy-mediated degradation via the KLHL20–ULK1 axis to balance ectodermal and mesodermal lineage commitment.
#STTT #OpenAccess: doi.org/10.1038/s413...
