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@tomkindlon.bsky.social Oct 4, 2026, 10:16 PM

New from France

Interesting long Covid research where all participants satisfy ME/CFS criteria

Evidence for transcriptomic changes impacting muscle contraction in patients with post-acute COVID-19 syndrome

www.sciencedirect.com/science/arti...

#LongCovid #MEcfs #PwME #CFS #postcovid #postcovid19

Post-acute COVID-19 syndrome (PACS) overlaps with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) but, due to frequent muscle pain and exertional intolerance, neuromuscular disorders are often suspected. We report the results of a comprehensive neuromuscular evaluation in 27 PACS patients (22F/5M; median age 41 ys). All patients developed chronic fatigue (>6 months), post-exertional malaise, and cognitive impairment, with muscle pain in 88% but no neuromuscular deficits at clinical examination. 18/27 patients were unable to work. All patients fulfilled established ME/CFS diagnostic criteria (CDC 1994, ICC 2011, Inst Medicine 2015, NICE 2021). Electrophysiological studies and CK levels were normal. Brain 18FDG-PET/MRI (14/27) showed posterior hypometabolism in 8/14. Muscle biopsy (7/27) showed moderate dysimmune changes in 2/7. Exploratory transcriptomic analyses performed in muscle biopsies from PACS patients and pre-COVID controls unveiled in PACS differentially expressed genes in the cytokine and autophagy pathways. Interestingly, other genes were also differentially expressed in pathways affecting actin, the cytoskeleton, and contraction. Indeed, we found upregulated genes involved in the troponin-tropomyosin complex, a key regulator of muscle contraction through calcium binding. We also found downregulated genes involved in the formation and stabilization of actin bundles at sarcomere Z discs and in mechanical signaling. These findings indicate that PACS patients with prominent muscular symptoms do not exhibit overt neuromuscular involvement on standard investigations but may show subtle myopathic or dysimmune changes and central metabolic alterations. At the transcriptomic level, the data show an impact on key pathways involved in contraction. The overlap with ME/CFS highlights the importance of careful differential diagnosis and suggests a complex pathophysiology beyond a basic muscle disease.

@dgspsoa.eurosky.social Oct 4, 2026, 7:10 PM

Für mich ist die Suche nach Einwahldaten und Login bei der Bank 'Hacking'.

#Brainfog
#PAIS
#MEcfs
#PostCOVID

@kikkererwtje.bsky.social Oct 2, 2026, 4:28 PM

Postcovid lijkt best wel op ADHD, of niet?

#postcovid

@apresj20.bsky.social Oct 2, 2026, 3:27 PM

🔗 Les modalités d'inscription sont à retrouver ici :

#CovidLong #LongCovid #DemystifyingLongCovid #ApresJ20
#MedicalConference #POSTCOVID #COVID19 #ClinicalPractice #COVIDResearch #MedicalEducation #Research #LONGCOVIDINTL @academicmededu.bsky.social

@tomkindlon.bsky.social Oct 2, 2026, 12:41 AM

From Sweden

Booster dose of COVID-19 vaccine and its effectiveness against post COVID-19 condition in individuals with pre-existing immunity

www.thelancet.com/journals/ecl...

Screenshot from Science for ME update

#LongCovid #PASC #PwLC #postcovid #postcovid19 #PostCovidSyndrome

Booster dose of COVID-19 vaccine and its effectiveness against post COVID-19 condition in individuals with pre-existing immunity: a sequential propensity score-matched cohort study — Morris et al
"we demonstrate that receiving a fourth dose of COVID-19 vaccine is associated with a decreased risk of being diagnosed with post COVID-19 condition during the first 6 months after vaccination, although the incidence rate difference was small."
Article | Thread

@frieke72.mastodon.social.ap.brid.gy Oct 1, 2026, 7:31 PM

Interview of @georgemonbiot.bsky.social about the Guardian opinion, by David Tuller. With more details.
https://youtu.be/MaaeQ7crLz4

#mecfs #longcovid #postcovid #lyme #qkoorts

@mecfs @longcovid

@tomkindlon.bsky.social Oct 1, 2026, 12:34 AM

From the UK

An Open-Label Feasibility Study of Remdesivir in Long COVID: Results from the ERASE LC Trial

dx.doi.org/10.1093/oxfi...

Screenshot from latest Science for ME weekly update

#LongCovid #PASC #PwLC #postcovid #postcovid19

An Open-Label Feasibility Study of Remdesivir in Long COVID: Results from the ERASE LC Trial — Faghy et al
"The mean (SD) distance achieved in the 6MWT was 408 (113) metres at baseline compared to 468 (109) metres post-intervention" "whilst improvements were observed in health-related quality of life, the mean change in EQ-5D-5L index score (0.06) did not exceed the published MCID of 0.11" "Improvements could reflect natural fluctuation in symptom burden, behavioural modification associated with trial participation, or expectation effects."
Article | Thread

@bodape.bsky.social Sep 30, 2026, 9:29 PM

Morgen wichtiger Termin! 🚨
Donnerstag, 01.10.2026 10:00 Uhr Bundespressekonferenz postinfektiöse Erkrankungen, Versorgung, Forschung und Prävention am Beispiel von Long Covid.

Bitte teilen und weitersagen!
Live-Audio:
www.deutschlandradio.de/dokumente-un...
#LongCovid #PostCovid #MECFS

In der Bundespressekonferenz geht es um postinfektiöse Erkrankungen, Versorgung, Forschung und Prävention am Beispiel von Long Covid

@nichtgenesen.bsky.social Sep 30, 2026, 8:56 PM

…die Pressekonferenz live als Tonspur.
Ein Termin, den Betroffene, Angehörige und Interessierte auf dem Schirm haben sollten.
Bitte teilen und weitersagen!
Live-Audio:
www.deutschlandradio.de/dokumente-un...
#LongCovid #PostCovid #MECFS #Bundespressekonferenz #Leopoldina

@meassociation.org.uk Sep 30, 2026, 2:31 PM

Post-COVID Gastrointestinal Symptoms and Disorders of Gut-Brain Interaction: A Focus on Persistent Diarrhea

Read more, and Dr Shepherd's comments: https://meassociation.org.uk/glbn

#LongCovid #PostCovid

@tomkindlon.bsky.social Sep 30, 2026, 12:30 AM

The Post-Acute Effects of COVID-19 Are Not Associated with Robust Long-Term Regional or Global Brain Volumetric Changes: A Bayesian Meta-Analytic Evidence

www.sciencedirect.com/science/arti...

Screenshot from Science for ME update

#LongCovid #NeuroPASC #COVIDBrain #PASC #postcovid #postcovid19

The Post-Acute Effects of COVID-19 Are Not Associated with Robust Long-Term Regional or Global Brain Volumetric Changes: A Bayesian Meta-Analytic Evidence — Costa et al
"our focused examination of both global and regional volumetric changes not only provides deeper spatial insights compared to previous primary studies but also addresses the substantial methodological heterogeneity" "Results highlighted that while either global or local alteration was reported by independent studies, this evidence remains unsupported when they are considered on a meta-analytic level."

@bassjobsen.mastodon.nl.ap.brid.gy Sep 29, 2026, 5:31 PM

#PostCovid #LongCovid Liefst 88% na 2,5 jaar nog ziek, 65% kan niet meer (volledig) werken. En er is géén medicijn.
Hoe we dit beleidsmatig negeren en weigeren de bron (airborne transmissie op de werkvloer/school) aan te pakken via ventilatie/HEPA is een historische blunder.
📰 […]

@heytheremaggs.bsky.social Sep 29, 2026, 5:15 PM

Hi #LongCovid / #MECFS friends. What is the going feeling on the actively recruiting phase 3 Baricitinib trial?

#NEISvoid #ClinicalTrial #Study #Science #Covid #RCT #REVERSE-LC #PostCovid #Covid19 #PASC #MoHashtagsMoProblems

@susantje.bsky.social Sep 29, 2026, 5:01 AM

#longcovid #postcovid #nieuwNederlandsSchandaal #weggemoffeld #expertisecentra @robjetten.bsky.social @mirjambikker.bsky.social @laurensdassen.voltnederland.org @jesseklaver.progressiefnederland.nl @jesseklaverpro.bsky.social @julianbushoff.bsky.social @partijvoordedieren.nl

@susantje.bsky.social Sep 29, 2026, 4:57 AM

#longcovid #postcovid @robjetten.bsky.social #schandalig #vergetenenweggemoffeld