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@nsrhighlights.bsky.socialSep 28, 2026, 12:15 PM

In a brainstem-seeded mouse model, REM-sleep abnormalities appeared before motor deficits and dopamine-neuron loss.

https://doi.org/10.1016/j.neures.2026.105023
#NeuroscienceResearch #Neuroscience #Parkinsons

Japanese painterly NSR cover showing a brainstem-to-motor time path in a mouse model; an early disrupted sleep gate; and later motor imbalance and dopaminergic-cell loss markers kept downstream in time. The canonical explorer walks along the timeline, pausing first at the sleep gate and later at the motor gate. A small washi banner reads Neuroscience Research.
@nsrhighlights.bsky.socialSep 28, 2026, 12:15 PM

運動障害が現れる前に、睡眠の異常を捉えられるでしょうか。変異型αシヌクレイン線維を脳幹へ入れたマウスでは、REM睡眠中の異常が先に現れ、その後に運動障害とドーパミン神経の減少が続きました。

https://doi.org/10.1016/j.neures.2026.105023
#NeuroscienceResearch #Neuroscience #Parkinsons

Japanese painterly NSR cover showing a brainstem-to-motor time path in a mouse model; an early disrupted sleep gate; and later motor imbalance and dopaminergic-cell loss markers kept downstream in time. The canonical explorer walks along the timeline, pausing first at the sleep gate and later at the motor gate. A small washi banner reads Neuroscience Research.
@nsrhighlights.bsky.socialSep 27, 2026, 12:15 PM

ERK activity in awake mouse cortex was not only stimulus-driven: spontaneous single, repeated, and sustained signals appeared, and some neurons changed together.

https://doi.org/10.1016/j.neures.2026.105032
#NeuroscienceResearch #Neuroscience #ERK

Japanese painterly NSR cover showing a field of awake cortical cells; distinct single, repeated, and sustained ERK pulse patterns; and a subset of neighboring excitatory neurons with synchronized pulses. The canonical explorer watches several cell lanterns and marks when their pulse rhythms align or diverge. A small washi banner reads Neuroscience Research.
@nsrhighlights.bsky.socialSep 27, 2026, 12:15 PM

覚醒中の脳で、細胞内のERK信号は刺激を待っているだけではありませんでした。マウス皮質を長時間観察すると、刺激なしでも単発・反復・持続する活動が現れ、一部の神経細胞では活動が同期しました。

https://doi.org/10.1016/j.neures.2026.105032
#NeuroscienceResearch #Neuroscience #ERK

Japanese painterly NSR cover showing a field of awake cortical cells; distinct single, repeated, and sustained ERK pulse patterns; and a subset of neighboring excitatory neurons with synchronized pulses. The canonical explorer watches several cell lanterns and marks when their pulse rhythms align or diverge. A small washi banner reads Neuroscience Research.
@nsrhighlights.bsky.socialSep 26, 2026, 12:15 PM

What keeps developing cortical neurons inside the brain’s outer boundary? In mice, CD81 linked neuronal GPR56 signaling with a collagen III scaffold in the meninges.

https://doi.org/10.1016/j.neures.2026.105035
#NeuroscienceResearch #Neuroscience #Cortex

Japanese painterly NSR cover showing a recognizable layered developing cortical wall; three interacting CD81, GPR56, and collagen-III conceptual forms; and a cortical-boundary defect in the double-knockout comparison. The canonical explorer compares an intact cortical boundary with a disrupted one while tracing the three-part interaction. A small washi banner reads Neuroscience Research.
@nsrhighlights.bsky.socialSep 26, 2026, 12:15 PM

発達中の大脳皮質で境界はどう保たれる? マウスでは、膜タンパク質CD81が神経側のGPR56や髄膜側のコラーゲンIIIと協調し、皮質の境界と層構造を支えることが示されました。

https://doi.org/10.1016/j.neures.2026.105035
#NeuroscienceResearch #Neuroscience #Cortex

Japanese painterly NSR cover showing a recognizable layered developing cortical wall; three interacting CD81, GPR56, and collagen-III conceptual forms; and a cortical-boundary defect in the double-knockout comparison. The canonical explorer compares an intact cortical boundary with a disrupted one while tracing the three-part interaction. A small washi banner reads Neuroscience Research.
@nsrhighlights.bsky.socialSep 25, 2026, 12:15 PM

In noise-exposed mice, a multicomponent herbal formulation reached the inner ear, reduced worsening of auditory brainstem responses, and lowered an oxidative-stress marker.

https://doi.org/10.1016/j.neures.2026.105043
#NeuroscienceResearch #Neuroscience #Hearing

Japanese painterly NSR cover showing a recognizable cochlear spiral; auditory response waves before and after treatment-associated attenuation; and localized oxidative-stress sparks reduced in the comparison condition. The canonical explorer listens at the cochlear spiral and compares two response-wave ribbons without dispensing treatment. A small washi banner reads Neuroscience Research.
@nsrhighlights.bsky.socialSep 25, 2026, 12:15 PM

騒音で傷んだ内耳へ、多成分の生薬製剤は届くのでしょうか。マウスでは複方丹参滴丸の成分が内耳へ移行し、音に対する脳幹反応の悪化が小さくなり、酸化ストレスの指標も低下しました。

https://doi.org/10.1016/j.neures.2026.105043
#NeuroscienceResearch #Neuroscience #Hearing

Japanese painterly NSR cover showing a recognizable cochlear spiral; auditory response waves before and after treatment-associated attenuation; and localized oxidative-stress sparks reduced in the comparison condition. The canonical explorer listens at the cochlear spiral and compares two response-wave ribbons without dispensing treatment. A small washi banner reads Neuroscience Research.
@nsrhighlights.bsky.socialSep 24, 2026, 12:15 PM

Focal CRTC1 reduction in marmoset visual cortex changed rapid-response genes and fast electrical rhythms beyond the targeted area, while local tissue showed neurodegeneration.

https://doi.org/10.1016/j.neures.2026.105042
#NeuroscienceResearch #Neuroscience #CRTC1

Japanese painterly NSR cover showing a recognizable cortical sheet with a localized injection zone; concentric immediate-early-gene response zones extending outward; and transient high-frequency wave bursts alongside progressive tissue injury. The canonical explorer observes the expanding boundary from a safe overlook and records its changing phases. A small washi banner reads Neuroscience Research.
@nsrhighlights.bsky.socialSep 24, 2026, 12:15 PM

霊長類の視覚野でCRTC1を局所的に減らすと、変化は周囲へ広がりました。マーモセットでは、神経活動に素早く反応する遺伝子と速い脳波リズムが変わり、局所で神経変性も進みました。

https://doi.org/10.1016/j.neures.2026.105042
#NeuroscienceResearch #Neuroscience #CRTC1

Japanese painterly NSR cover showing a recognizable cortical sheet with a localized injection zone; concentric immediate-early-gene response zones extending outward; and transient high-frequency wave bursts alongside progressive tissue injury. The canonical explorer observes the expanding boundary from a safe overlook and records its changing phases. A small washi banner reads Neuroscience Research.
@nsrhighlights.bsky.socialSep 23, 2026, 12:15 PM

In mice given a lipid-lowering drug before an induced stroke, brain injury was milder: damaged tissue volume and neurological deficits were reduced at 48 hours.

Sep 18, 2026
https://doi.org/10.1016/j.neures.2026.105121
#NeuroscienceResearch #Neuroscience

和紙の風合いの日本画風イラスト。白いマウスのそばで、猫の探検家が虫眼鏡を持ち、脳の形の紙模型に置かれた赤い血管と小さな留め具を観察する。脇に閉じた薬瓶と無地の札が並ぶ。マウスの一時的な脳血流遮断と事前投薬の研究を表す概念画で、実際の脳画像や治癒の描写ではない。下部にNeuroscience Researchの和紙看板。
@nsrhighlights.bsky.socialSep 23, 2026, 12:15 PM

脂質を下げる薬を脳梗塞前から投与したマウスでは、脳の傷害が軽くなりました。48時間後に、梗塞の体積が小さく、神経症状も軽くなっていました。

2026.9.18
https://doi.org/10.1016/j.neures.2026.105121
#NeuroscienceResearch #Neuroscience

和紙の風合いの日本画風イラスト。白いマウスのそばで、猫の探検家が虫眼鏡を持ち、脳の形の紙模型に置かれた赤い血管と小さな留め具を観察する。脇に閉じた薬瓶と無地の札が並ぶ。マウスの一時的な脳血流遮断と事前投薬の研究を表す概念画で、実際の脳画像や治癒の描写ではない。下部にNeuroscience Researchの和紙看板。
@nsrhighlights.bsky.socialSep 21, 2026, 12:15 PM

In six adults, wearable OPM-MEG detected a steady 30-Hz visual response near cortex, while slower transient signals were hidden by movement noise.

https://doi.org/10.1016/j.neures.2026.105052
#NeuroscienceResearch #Neuroscience #MEG

Japanese painterly NSR cover showing a wearable OPM sensor array around the head; a 30-Hz checkerboard visual source; and contralateral steady-state response waves contrasted with low-frequency motion artifact. The canonical explorer balances an OPM lantern and an EEG lantern while watching the 30-Hz wave. A small washi banner reads Neuroscience Research.
@nsrhighlights.bsky.socialSep 21, 2026, 12:15 PM

頭に装着する小型磁気センサーで、視覚刺激に同期する脳活動を測れる? 健康な成人6人では、ウェアラブルOPM-MEGが30Hzの定常応答を視覚野近くで捉えました。一方、遅い一過性応答は動きの雑音に隠れました。

https://doi.org/10.1016/j.neures.2026.105052
#NeuroscienceResearch #Neuroscience #MEG

Japanese painterly NSR cover showing a wearable OPM sensor array around the head; a 30-Hz checkerboard visual source; and contralateral steady-state response waves contrasted with low-frequency motion artifact. The canonical explorer balances an OPM lantern and an EEG lantern while watching the 30-Hz wave. A small washi banner reads Neuroscience Research.
@nsrhighlights.bsky.socialSep 20, 2026, 12:15 PM

Can the timing of ultrasound pulses reverse their effect at the same acoustic intensity? In a 13-person pilot, two ten-pulse patterns shifted motor-evoked potentials in opposite directions.

https://doi.org/10.1016/j.neures.2026.105055
#NeuroscienceResearch #Neuroscience #Ultrasound

Japanese painterly NSR cover showing two distinct decapulse ultrasound trains; a recognizable motor-cortex target; and motor-evoked-response ribbons diverging upward and downward. The canonical explorer stands between the two pulse trains and compares their opposite response directions. A small washi banner reads Neuroscience Research.
@nsrhighlights.bsky.socialSep 20, 2026, 12:15 PM

同じ強さの超音波でも、パルスの並べ方で運動皮質の反応は逆になる? 健康な13人の予備研究では、2種類の10パルス刺激が、筋肉に現れる運動誘発電位を一方は高め、もう一方は低下させました。

https://doi.org/10.1016/j.neures.2026.105055
#NeuroscienceResearch #Neuroscience #Ultrasound

Japanese painterly NSR cover showing two distinct decapulse ultrasound trains; a recognizable motor-cortex target; and motor-evoked-response ribbons diverging upward and downward. The canonical explorer stands between the two pulse trains and compares their opposite response directions. A small washi banner reads Neuroscience Research.
@nsrhighlights.bsky.socialSep 19, 2026, 12:15 PM

Autotaxin, a lipid-signal-producing enzyme, was not uniform in mouse brain. It stood out on the fluid-facing side of choroid plexus cells and in myelin-forming oligodendrocytes.

https://doi.org/10.1016/j.neures.2026.105062
#NeuroscienceResearch #Neuroscience #BrainLipids

Japanese painterly NSR cover showing a recognizable choroid plexus facing a ventricular-CSF space; autotaxin-enriched apical epithelial surfaces; and a developmental shift toward oligodendrocyte-associated localization. The canonical explorer surveys the CSF-facing surface, then follows the age path toward oligodendrocytes. A small washi banner reads Neuroscience Research.
@nsrhighlights.bsky.socialSep 19, 2026, 12:15 PM

脂質シグナルを作る酵素autotaxinは、脳内に一様ではありませんでした。マウスでは、髄液を作る脈絡叢の髄液側と、軸索を包むオリゴデンドロサイトで際立ち、発達に伴って分布が変わりました。

https://doi.org/10.1016/j.neures.2026.105062
#NeuroscienceResearch #Neuroscience #BrainLipids

Japanese painterly NSR cover showing a recognizable choroid plexus facing a ventricular-CSF space; autotaxin-enriched apical epithelial surfaces; and a developmental shift toward oligodendrocyte-associated localization. The canonical explorer surveys the CSF-facing surface, then follows the age path toward oligodendrocytes. A small washi banner reads Neuroscience Research.
@nsrhighlights.bsky.socialSep 18, 2026, 1:23 PM

Mice making a disease-linked protein in a smell-processing brain region struggled to distinguish patterns, despite little detectable protein in visual areas.
📅 Published: Sep 11, 2026
🔗 https://doi.org/10.1016/j.neures.2026.105118
#NeuroscienceResearch #Neuroscience

和室の木製T字迷路で、黒いマウスが縦縞と横縞の目印に向かい、猫の探検家がしゃがんで観察しています。奥の和紙には離れた琥珀色と青緑色の神経風モチーフ。視覚課題と遠隔領域の機能変化を表す概念画で、実際の配線図やタンパク質分布図ではありません。
@nsrhighlights.bsky.socialSep 18, 2026, 1:23 PM

においを受け取る脳領域に病気関連のタンパク質を作らせたマウスで、模様を見分ける成績が低下しました。視覚領域では、そのタンパク質は検出しにくいままでした。
📅 2026年9月11日公開
🔗 https://doi.org/10.1016/j.neures.2026.105118
#NeuroscienceResearch #Neuroscience

和室の木製T字迷路で、黒いマウスが縦縞と横縞の目印に向かい、猫の探検家がしゃがんで観察しています。奥の和紙には離れた琥珀色と青緑色の神経風モチーフ。視覚課題と遠隔領域の機能変化を表す概念画で、実際の配線図やタンパク質分布図ではありません。
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