This week's #ThrowbackThursday in JHC: "Immunohistochemical Assessment of Cardiac Macrophages in the Aged Fischer 344 Rat."
Click to read for FREE: bit.ly/4qvjnl8
@histochemicalsoc.bsky.social
@histochemicalsoc.bsky.socialThis week's #ThrowbackThursday in JHC: "Immunohistochemical Assessment of Cardiac Macrophages in the Aged Fischer 344 Rat."
Click to read for FREE: bit.ly/4qvjnl8
@sigtrans-sttt.bsky.socialWhat shapes #Immunotherapy response in #ESCC?
A single-cell immune atlas reveals central memory T-cell depletion in tumours and identifies PD-L1⁺ #macrophages and CD39⁺ tumour-infiltrating T cells as clinically relevant immune features.
@exo-beyondthecell.bsky.social🎙️New EXO Chats episode is live!
Why does inflammation persist in cystic fibrosis after CFTR correction?
Listen and explore macrophages and the lung microenvironment: sciexplor.com/exo/podcast/5
#CysticFibrosis #Macrophages #iPSC #TissueEngineering
@nicolasavilalab.bsky.socialSome previous work suggested that captured mitochondria can integrate into recipient macrophage’s mitochondrial networks. Using genetic models to label parenchymal #mitochondria, we instead find continuous transfer to #macrophages at homeostasis, followed by #degradation 🚮
@nicolasavilalab.bsky.socialTwo independent multi-tissue screens pointed to the same tissues: #mitochondrial_transfer to #macrophages is highest in the #heart❤ , #brown_adipose_tissue (BAT) 🔥and #skeletal_muscles💪 . Importantly, differences in macrophage phagocytic activity could not explain this pattern
@nicolasavilalab.bsky.socialPrevious works showed that #macrophages capture #mitochondria released by other cells in several tissues. But where is this transfer most active❓We screened macrophages across 16 tissues and found striking differences in #mitochondrial_uptake spanning several orders of magnitude