@sigtrans-sttt.bsky.social#WorldArthritisDay | October 12
#Arthritis research is uncovering inflammatory pathways and molecular targets that could advance diagnosis and targeted treatment.
#STTT explores signal transduction and targeted therapies across human diseases.
Read recent research: www.nature.com/sigtrans/
@sigtrans-sttt.bsky.socialUsing comprehensive #Multiomics analyses, researchers identify PLPP2-mediated phosphatidylethanolamine biosynthesis as a driver of #LiverRegeneration by promoting GLI1 stabilization and #Autophagy while alleviating #ERstress.
@sigtrans-sttt.bsky.socialHow does α7 integrin drive HPV-negative head and neck cancer (#HNSCC)?
Researchers reveal that ITGA7 regulates chromatin accessibility and gene expression through an AURKA-centered axis, identifying a potential #TherapeuticTarget. @tudresden.bsky.social
@writteninmusic.mastodon.nl.ap.brid.gyRecensie: Content Blocks – Hard Out
https://writteninmusic.com/albumrecensie/content-blocks-hard-out/
@sigtrans-sttt.bsky.socialResearchers reveal how #Connexin43-mediated mitochondrial transfer from mesenchymal stem cells activates PGC1α signaling, reducing #OxidativeStress and #Inflammation to improve renal recovery after #Ischemia-reperfusion injury.
@sigtrans-sttt.bsky.socialPost-translational modifications can coordinate metabolic and immune adaptation in #Cancer. This review links PTM networks to metabolic flux, cell fate, #ImmuneEvasion, and emerging targets for metabolic therapy and #Immunotherapy.
@sigtrans-sttt.bsky.socialHow does immune cell trafficking shape tumors and #Inflammation?
This review explores immune reservoirs, chemokine signaling, adhesion, metabolism, and #Microbiota as regulators and therapeutic targets for precision #Immunomodulation.
@sigtrans-sttt.bsky.socialHow do intrinsic and acquired mechanisms drive cancer drug resistance?
This review details the mechanisms underlying resistance, highlighting emerging therapeutic strategies for overcoming resistance in #PrecisionOncology.
#STTT #OpenAccess: doi.org/10.1038/s413...
#CancerResearch #Oncology
@sigtrans-sttt.bsky.social#Mitochondrial dysfunction contributes significantly to human disease pathogenesis.
This review connects #proteostasis, biogenesis, mitochondrial dynamics, and mitophagy with disease mechanisms and emerging therapeutic strategies. @ub.edu
@sigtrans-sttt.bsky.social#Mucosaltissues serve as primary pathogen entry points requiring specialized defenses.
A review of the immune mechanisms and #Vaccine delivery platforms that elicit local & systemic responses, as well as the challenges for next-gen #MucosalVaccines.
@sigtrans-sttt.bsky.social#TumorHeterogeneity challenges antigen-specific #Vaccination.
This review explores how in situ #CancerVaccines combine immunogenic cell death, advanced delivery, microenvironment modulation, and checkpoint blockade to broaden antitumor immunity.
#STTT #OpenAccess: doi.org/10.1038/s413...
@sigtrans-sttt.bsky.socialHow can next-generation personalized #CancerVaccines overcome #Immunosuppressive microenvironments?
This review evaluates mRNA, DNA, and #Nanovaccine platforms combined with checkpoint inhibitors for durable immunity.
@sigtrans-sttt.bsky.socialThis review links genomic and #Epigenetic changes, metabolic adaptation, immune escape, and therapy-driven selection to emerging evolution-guided strategies for #PrecisionOncology. @fudan-university.bsky.social
@sigtrans-sttt.bsky.socialENO1 connects #Glycolysis with #GastricCancer stemness by regulating ATP pools and lactate homeostasis, which coordinate AMPK/mTOR and PI3K/AKT signaling to promote EMT, self-renewal, migration, and invasion.
@sigtrans-sttt.bsky.socialCan light power stressed #Mitochondria? Engineered mt-EcGAPR uses ambient light to enhance ATP production and reduce ROS, suppressing ER stress–ATF6–GSDMD-mediated #Pyroptosis and protecting retinal ganglion cells.
#STTT #OpenAccess: doi.org/10.1038/s413...
#RetinalResearch #Neuroscience
@sigtrans-sttt.bsky.social#Piezo1 links mechanical cues to bone marrow stem-cell fate. Its activation suppresses the Ccl2–CCR2–NF-κB–Lcn2 inflammatory loop, limiting adipogenesis while promoting osteoblast differentiation and #boneformation. #Osteoporosis
@sigtrans-sttt.bsky.social#ArterialStiffness links vascular aging with #cardiovascular and end-organ damage. This review explores its structural and functional mechanisms, clinical measurement, and emerging strategies for personalized prevention and therapy.
#STTT #OpenAccess: doi.org/10.1038/s413...
#PrecisionMedicine
@sigtrans-sttt.bsky.socialNew first-line strategies are needed for metastatic #ColorectalCancer. The APICAL-CRC phase II trial finds promising #antitumor activity and manageable safety with sintilimab plus anlotinib in treatment-naïve patients.
#STTT #OpenAccess: doi.org/10.1038/s413...
#MetastaticCRC #Immunotherapy
@sigtrans-sttt.bsky.socialGlutamine #metabolism has diverse roles across health and disease. This review explores its links to #Cancer, #Neurodegeneration, metabolic and #cardiovasculardisorders, microbiome interactions, and emerging therapeutic strategies.
@sigtrans-sttt.bsky.socialCan microbial exposure strengthen pulmonary host defense?
#Pseudomonas aeruginosa LPS primes lung-resident NK cells through C3aR1, enhancing IFN-γ production and LFA-1-dependent adhesion to protect against #BacterialPneumonia.