🧬 Tissue repair is essential—but what happens when it doesn’t switch off? An interesting perspective on how persistent inflammation and repair programmes contribute to fibrosis, and where we might intervene.
#Immunology #Fibrosis

Zhang et al. identify RalA-dependent signaling as a regulator of age-related #skeletalmuscle dysfunction. The novel compound UA-30 inhibits RalA activity, reduces muscle #fibrosis, improves mitochondrial function & mobility, & extends health span & survival in mice. rupress.org/jem/article/...

BCL9 drives the MerTK–ERK–SPP1 macrophage M2 program in #PulmonaryFibrosis, while its inhibition reprograms macrophage–fibroblast crosstalk toward fibroblast #Lipogenesis, supports AT2 cell expansion and attenuates #Fibrosis.

#STTT #OpenAccess: doi.org/10.1038/s413...

#Hepatology #GileadSciences #Gilead #Livdelzi #seladelpar #Scotland #PBC #primarybiliarycholangitis #Pruritus #UDCA #NHSScotland #SMC #ScottishMedicinesConsortium #chronicitch #rarediseases #liverdisease #fibrosis #cirrhosis #liverfailure #PBCFoundation #RESPONSE #phase3
zurl.co/OHgLy

Exciting news! My group’s new in press preview is in @insight.jci.org insight.jci.org/articles/vie.... Detailed analysis of endothelial plasticity and characteristation of fibrosis-associated EC (FAEC) phenotypes in healthy tissue, models of liver fibrosis and MSALD patients. #EndMT #fibrosis

😀 We are pleased to welcome our speakers for the Main Session “Immunity in the Intestine”. www.immunology-conference.de

@efis-immunology.bsky.social @iuis-online.bsky.social @dgfi-yi.bsky.social

#immunology26 #dgfi #ImmunityInTheIntestine #Microbiome #Fibrosis #Inflammation #Immunology

Commentary: An NFATC4 phospho-switch links matrix stiffness to fibroblast fate: doi.org/10.1172/JCI2...

Rebecca Shelley Frabotta & Purushothama Rao Tata @dukemedschool.bsky.social discuss Kadri et al.: doi.org/10.1172/JCI1...
#Fibrosis