New research identifies MARCH7 as a key E3 ubiquitin ligase that regulates intracellular iron, acting as a dual suppressor of ferroptosis by ubiquitylating NCOA4. PMID:42049018, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00388-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

3'-UTR variants influence mRNA regulation, impacting alcohol use disorder risk. #GeneticsInFocus PMID:42374457, Genome Biol 2026 @OTSociety @NAR_Open https://doi.org/10.1186/s13059-026-04176-x #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Frequent prion-based switches in DNA repair proteins drive adaptive mutagenesis in Saccharomyces cerevisiae, enhancing evolution across diverse environments. PMID:42263676, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00577-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Heat stress boosts susceptibility to metabolic dysfunction when followed by an obesogenic diet in mice, driven by KLK14's impact on hypothalamic LRRC7⁺ astrocytes. PMID:42019490, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00346-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A study reveals >1,000 molecular changes in SOD1-G93A mouse motor neurons, leading to a new "disease-associated motor neuron" state, key to ALS progression. PMID:42335888, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00647-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A novel screening platform using 84 CRISPR-Cas9 mouse lines targets host factors crucial for understanding influenza A virus. This boosts in vivo functional validation! PMID:42302780, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600591X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A phytoscreen of 43 fruits/vegetables revealed garlic as a key deterrent of mating and egg laying in Drosophila and mosquitoes. Diallyl disulfide disrupts these behaviors! 🍏🦟 PMID:41999745, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00338-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New paleoproteomic analysis of 23 H. naledi dental enamel specimens from 20 individuals reveals no male markers, suggesting a single-sex sample in a unique population. PMID:42341758, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00644-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Arabidopsis seeds pack histone variant H2B.8, arranging 3D nuclear space. Upon imbibition, H2B.8 is evicted, hinting at chromatin reprogramming in seed-to-seedling transition! PMID:42373623, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74230-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

71F with speech, gait issues, hearing loss found with infratentorial superficial siderosis & T-spinal cord cleft. Fascinating case! PMID:42371616, JAMA Neurol 2026, @JAMANeuro https://doi.org/10.1001/jamaneurol.2026.1992 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Discoveries in viral replication: UL9 protein of HSV-1 forms DNA tethers and loops at oriS. A direct view into herpesvirus genome replication mechanisms. PMID:42373616, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74361-w #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

2'3'-cGAMP activates a unique 3TM-SMODS model promoting membrane shearing in anti-phage immunity, revealing novel insights into prokaryotic antiviral defenses. PMID:41999741, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00344-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

12 cave lion genomes from over 100,000 years reveal distinct lineages from modern lions, with unique variants and signs of ancient gene flow. Evolutionary secrets uncovered! PMID:42235515, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00524-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Noninvasive neuroprosthesis breakthrough: Brain2Qwerty decodes sentences from brainwaves in 35 volunteers. High potential with no surgery needed! #Neurotech PMID:42374156, Nat Neurosci 2026, @NatureNeuro https://doi.org/10.1038/s41593-026-02303-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Autoimmune encephalitis research hits a plateau in novel autoantibody discovery. Shifting focus may better aid patients. PMID:42371641, JAMA Neurol 2026, @JAMANeuro https://doi.org/10.1001/jamaneurol.2026.1659 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A new model analyzes mammalian cortical connectomes, revealing that spatial constraints design unique connectivity profiles across regions in complex networks. PMID:42361798, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00648-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study of 3.6M+ adults in Chile shows severe COVID-19 may increase TB risk. Urgent need for monitoring post-COVID recovery! Let's discuss the implications. PMID:42373634, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74528-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study identifies >1,000 somatic variants in 311 AD brain samples, linking cancer driver genes, clonal hematopoiesis, and neuroinflammation via microglia-like cells. PMID:42019491, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00341-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Thank you @shihcheng.bsky.social for sharing this elegant study, fusing Ca²⁺ imaging, morphology & in situ transcriptomics for 30 neurons.
We are pleased to find and highlight research like this.
Follow @academaxjournals.bsky.social for similar #STEM studies.

#MedEdsky #RNA #ASHG #ESHG

A novel trimodal platform integrates in vivo Ca²⁺ imaging, detailed neuron morphology, and in situ transcriptomics, linking neuronal activity to function for 30 neurons. PMID:42314668, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00641-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪