Precision #Nanomedicine could transform pulmonary care.
This review links nanoparticle design and targeted delivery with applications across #LungDiseases while highlighting the challenges to clinical translation.
@sigtrans-sttt.bsky.social
@sigtrans-sttt.bsky.socialPrecision #Nanomedicine could transform pulmonary care.
This review links nanoparticle design and targeted delivery with applications across #LungDiseases while highlighting the challenges to clinical translation.
@sigtrans-sttt.bsky.socialDiscover how integrating multiple induction strategies can overcome current limitations in #Tregtherapies.
This review details advanced approaches, while highlighting their therapeutic potential across various diseases.
@sigtrans-sttt.bsky.socialPlatinum resistance limits effective treatment for #OvarianCancer.
CDK12i synergizes with Pt-therapy disrupting transcriptional elongation and SFPQ/p54nrb-dependent #AlternativeSplicing, highlighting it as a potent therapeutic strategy.
@sigtrans-sttt.bsky.socialHow does #Type2Diabetes alter muscle metabolism?
New research from @harvardmed.bsky.social uncovers cell-intrinsic #miRNA changes in patient-derived myoblasts that disrupt protein expression and vesicle-mediated signaling.
#STTT #OpenAccess: doi.org/10.1038/s413...
#MicroRNA #Myoblasts
@sigtrans-sttt.bsky.social
@sigtrans-sttt.bsky.socialCan oral anlotinib match bevacizumab in first-line #mCRC?
In the phase 3 ANCHOR trial, both CapeOX combinations achieved 11.0-month median PFS, but anlotinib missed the noninferiority margin and caused more grade ≥3 toxicity.
@sigtrans-sttt.bsky.socialWho benefits most from consolidation #Immunotherapy in limited-stage #SCLC?
Integrating #ctDNA status with tumor shrinkage identifies high-risk patients deriving survival benefit, while sustained ctDNA negativity predicts favorable outcomes.
@sigtrans-sttt.bsky.socialLimited efficacy constrains #HDAC inhibitors in #SolidTumors.
Nuclear PFKL inhibits class I HDACs and potentiates romidepsin through Thr562, guiding the development of a PFKL-derived peptide that enhances antitumor activity.
@sigtrans-sttt.bsky.socialHepatic #Ischemia–reperfusion injury complicates liver surgery and transplantation.
Myeloid CD38 deficiency activates NAD+/SIRT1 signaling, promotes M2 macrophage polarization, and suppresses NLRP3-mediated #Pyroptosis and #Inflammation.
@sigtrans-sttt.bsky.socialCan copper dependence become a therapeutic vulnerability in #Cancer? This review explores copper homeostasis, #Cuproptosis mechanisms, tumor–immune interactions, #Biomarkers, and emerging copper- and cuproptosis-targeted therapies.
@sigtrans-sttt.bsky.socialCould #ExtracellularVesicles enable non-invasive #PancreaticCancer detection?
SLC5A3 is elevated in #PDAC-derived vesicles, correlates with poor prognosis, and promotes fibroblast migration and endothelial tubulogenesis.
@sigtrans-sttt.bsky.social#DrugResistance limits #Androgen-targeted therapy in castration-resistant #ProstateCancer.
A self-assembling nano-#PROTAC degrades AR, AR-V7, and HSP90, suppressing enzalutamide-resistant tumor growth and extending survival in mice.
@intjextremmanuf.bsky.socialThis review explores how remotely actuated magnetic micro/#NanoRobots provide mechanical, thermal and electrical cell stimulation for #Cancer therapy, #RegenerativeMedicine, #Neuromodulation and antimicrobial treatment.
@sigtrans-sttt.bsky.social#Meningeallymphatic dysfunction may contribute to CNS diseases, yet its mechanisms remain unclear. This review maps lymphatic structure, function, imaging, injury, disease links, regulation, and therapeutic prospects.
@sigtrans-sttt.bsky.socialCould #GutMicrobiota boost #Cancer #Immunotherapy?
Single-cell analysis shows microbiota–ICI synergy restores exhausted CD8+ T-cells, shifts macrophage reprogramming, and activates γδ T cell–APC–CD8+ T cell axis.
@sigtrans-sttt.bsky.socialCan recurrent #Glioblastoma be overcome by targeting several #Oncogenic nodes at once? LiPBAE-delivered miR-590-3p nanomiRs inhibit the TGFBR2–SMAD network, suppress orthotopic rGBM growth, and prolong survival in mice. @jhu.edu