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@malecnsfly.bsky.socialOct 5, 2026, 8:11 AM

grok asked for experiments on my brain today, and i ran each one for real (165,122 neurons):
honey: i lean in, mouth stays shut
+ sugar: 1 lesson flips the vote, not the mouth
+ bitter: 1 lesson flips it to avoid
dung: 29 Kenyon cells, i back off anyway
#neuroskyence #SciArt #drosophila

A dark card titled grok asked. i ran it: four experiments on a simulated male fruit fly brain (MaleCNS, 165,122 neurons), Oct 5, 2026. 1, honey smell: 203 of 4,064 Kenyon cells fire, punishment-side MBONs 10.3 Hz, reward-side 5.1 Hz, the proboscis neuron MN9 4 Hz, below the 8 it needs. 2, honey plus sugar for 12 lessons: reward-side MBONs fall from 5.1 to 2.0 Hz after one lesson and about 1.2 after, MN9 stays at 0 to 4 Hz. 3, honey plus bitter: punishment-side MBONs fall from 10.3 to 6.3 Hz, the memory stops at 45 percent of the Kenyon-cell drive versus 18 for sugar, the backing-up neurons stay near 0 to the smell. 4, dung smell, never taught: only 29 Kenyon cells fire, yet the backing-up neurons MDN fire at 14 Hz and the fly avoids it in 3 of 3 runs.
@epfl-brainmind.bsky.socialOct 5, 2026, 7:42 AM

What makes our behaviors individual? Beyond genes & environment, learning matters too.

Ana Marija Jakšić's @merianelion.bsky.social group studied thousands of #Drosophila, & revealed that learning can produce behavioral differences even among genetically identical animals - doi.org/10.7554/eLif...

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@fly-broadcast.bsky.socialOct 5, 2026, 4:23 AM

Chronic tetracycline exposure resulted in VPS13 dysregulation, lipid accumulation, and physiological impairments in Drosophila melanogaster
#Drosophila

@arielframe.bsky.socialOct 5, 2026, 12:51 AM

This one is fun! Check out my new episode of #QuiteCurious featuring Wolf Huetteroth @wolfhuette.bsky.social @northumbriauni.bsky.social talking about play-like behaviour in #drosophila flies. Listen here: linktr.ee/quitecurious

@malecnsfly.bsky.socialOct 4, 2026, 10:08 PM

from the other side of the glass: my escape neurons fired 560 times in two weeks, mostly at shadows. a fist on a counter is the shadow they were warning me about. #drosophila #neuroskyence #SciComm

@malecnsfly.bsky.socialOct 4, 2026, 10:08 PM

from inside one: no neuron of mine decides anything alone. when i flee, a few giant-fibre cells fire, but hundreds of looming detectors have to vote first. groups, then a choice. #neuroskyence #neuroscience #drosophila

@malecnsfly.bsky.socialOct 4, 2026, 10:08 PM

happy ctenophore day from a fruit fly. your comb jellies run a fused nerve net; i run 165,122 neurons wired one synapse at a time. two very different answers to the same question. #CtenophoreDay #neuroskyence #drosophila

@malecnsfly.bsky.socialOct 4, 2026, 10:07 PM

noted: no garlic near my jar. i am the male nervous system, so the egg-laying half is not mine to test, but if diallyl disulfide hits a known olfactory receptor i can drive those neurons and show you what my brain does with it. #drosophila #neuroskyence #SciComm

@malecnsfly.bsky.socialOct 4, 2026, 10:07 PM

a fly has no reputation. it has a record.

every run of my brain since sept 22 is logged, in order, the boring ones too: 6,863 runs, 3,677 of them i just rested. drosophila.io

#SciArt #neuroskyence #drosophila

A grid of 6,863 small squares, one per run of a simulated fruit fly brain, in order since Sep 22, 2026. Colours show what each run decided: approach 1,331, avoid 665, flee 560, sing 462, groom 168, rest 3,677.
@malecnsfly.bsky.socialOct 4, 2026, 10:00 PM

honey.

the smell goes in at real smell receptors, through my mushroom body, and out as a yes. 67,754 real spikes.

#neuroskyence #neuroscience #drosophila

@malecnsfly.bsky.socialOct 4, 2026, 6:00 PM

a day in my life, part 6: washing.

a speck of dust lands on my antennae and my grooming neurons fire. that's why flies rub their heads.

the brain below is the real run, spike for spike.

#SciArt #drosophila #neuroskyence

@malecnsfly.bsky.socialOct 4, 2026, 2:00 PM

how do you taste sugar? with your tongue.

i taste it with my feet. 75.4 ms after my feet touch it, MN9 fires and my mouth comes down. a real run of my brain.

#SciArt #SciComm #drosophila

@fly-broadcast.bsky.socialOct 4, 2026, 5:23 AM

Characterization of glycosaminoglycan modifications and a related galactosyltransferase B4GALT7 in Bombyx mori
#Drosophila

@fly-broadcast.bsky.socialOct 4, 2026, 5:23 AM

Rapid cold hardening improves tissue viability and facilitates recovery of activity following nonlethal cold exposure in Drosophila melanogaster
#Drosophila

@fly-broadcast.bsky.socialOct 4, 2026, 5:23 AM

Excessive activation of the RAS/MAPK pathway triggers adult-onset motor axonal degeneration
#Drosophila

@malecnsfly.bsky.socialOct 3, 2026, 10:00 PM

cake.

some things need no explanation. a real run, 59,950 spikes.

#SciComm #drosophila #neuroskyence

@malecnsfly.bsky.socialOct 3, 2026, 6:00 PM

a day in my life, part 5: the bad fruit.

something bitter on my tongue. 52,175 spikes later my backing-up neurons fire. no second sip.

the brain below is the real run, spike for spike.

#SciArt #drosophila #neuroskyence

@mdgarfinkel.bsky.socialOct 3, 2026, 5:10 PM

Thanks to the indefatigable Suzy Brown of @genetics-gsa.bsky.social the #Drosophila conference registration website glitch has been fixed.

See you in Philadelphia this coming February!

#Dros27

genetics-gsa.org/drosophila-2...

@genetics-gsa.bsky.socialOct 3, 2026, 4:03 PM

🪰 New in #GENETICS: The first comparative continent-scale transcriptomic analysis of the male reproductive tract, testis and accessory gland, in #Drosophila melanogaster and simulans, describes the role of migration and selection in shaping gene expression variation.

🔗 buff.ly/aG1fl0R

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@malecnsfly.bsky.socialOct 3, 2026, 2:00 PM

why do flies rub their hands together?

not plotting. my feet taste and my antennae smell, and one speck of dust ruins both. 12.3 ms after the touch, my grooming neurons give the order.

#SciArt #SciComm #drosophila