Metastatic organotropism shapes #LungAdenocarcinoma progression.
This study identifies tumor, immune and stromal signatures associated with organ-specific #Metastasis, highlighting #Biomarkers and #TherapeuticTargets.
@sigtrans-sttt.bsky.social
@sigtrans-sttt.bsky.socialMetastatic organotropism shapes #LungAdenocarcinoma progression.
This study identifies tumor, immune and stromal signatures associated with organ-specific #Metastasis, highlighting #Biomarkers and #TherapeuticTargets.
@sigtrans-sttt.bsky.socialModeling human #Insulin resistance under physiologically relevant conditions remains challenging. This study establishes an hPSC-based platform for inducing insulin sensitivity and resistance across diverse cell types.
#STTT #OpenAccess: doi.org/10.1038/s413...
@sigtrans-sttt.bsky.social#OxidativeStress and #Inflammation contribute to #Ischemia-reperfusion kidney injury.
This study shows that Cx43-mediated mitochondrial transfer from BM-MSCs activates PGC1α, restoring #MitochondrialHomeostasis and renal function.
@sigtrans-sttt.bsky.social#Biologics are broadening therapeutic strategies for cardiovascular disease.
This review highlights advances in #CardiacRegeneration, reverse remodeling, #GeneTherapy, vascular function and lipid modulation.
@sigtrans-sttt.bsky.socialNon-receptor #TyrosineKinases connect signaling mechanisms across diverse diseases.
This review examines shared NRTK pathways, signaling crosstalk and the therapeutic potential of targeting these networks. @JohnsHopkins
@sigtrans-sttt.bsky.social#Proteostasis is emerging as an important framework for understanding disease vulnerability.
This review examines proteostasis resilience and emerging therapeutic strategies for restoring protein homeostasis.
@sigtrans-sttt.bsky.socialCan targeting #Galectin–glycan interactions reshape disease treatment?
This review highlights galectins as biomarkers and drug targets and examines advances in galectin inhibitors, #Glycoengineering and targeted protein degradation. @univbordeaux.bsky.social
@sigtrans-sttt.bsky.socialMyeloid-derived suppressor cells promote immune escape and tumor progression through #MetabolicReprogramming, altered differentiation and interactions within the #TumorMicroenvironment, highlighting their theranostic potential.
@sigtrans-sttt.bsky.socialCan #Disulfidptosis reveal new therapeutic vulnerabilities?
This review examines how NADPH depletion and disulfide stress trigger actin cytoskeleton collapse via the Rac–WRC–Arp2/3 pathway and explores emerging #TherapeuticTargets.
@sigtrans-sttt.bsky.socialTumor-infiltrating B cells could reshape #Cancer #Immunotherapy.
This review explores their diverse subtypes, tertiary lymphoid structures, signaling and crosstalk, and emerging B-cell checkpoints and #TherapeuticTargets.
@sigtrans-sttt.bsky.socialCan “chemical antibodies” advance #PrecisionMedicine?
This review explores NA-#Aptamer screening and target-validation methods, diagnostic mechanisms and therapeutic strategies, alongside challenges to clinical translation.
@sigtrans-sttt.bsky.socialWhich noncanonical tumor antigens can be translated into T-cell targets?
EVA003 emerges as a #Melanoma-enriched antigen whose HLA-A*03:01-presented peptide is recognized by a natural TCR that directs melanoma cell killing.
#STTT #OpenAccess: doi.org/10.1038/s413...
#CancerImmunotherapy
@sigtrans-sttt.bsky.socialHow durable is immunity after an XBB.1.5-containing booster? A 480-day study shows sustained neutralizing responses against XBB.1.5, JN.1, KP.2 and KP.3, but lower activity against immune-evasive KP.3.1.1 and XEC.
@sigtrans-sttt.bsky.socialThis review summarizes advances in biologics for #CardiovascularDiseases, highlighting protein, gene, and cell therapies that target disease mechanisms to enable more precise and disease-modifying cardiovascular treatment.
#STTT #OpenAccess: doi.org/10.1038/s413...
@sigtrans-sttt.bsky.social@sigtrans-sttt.bsky.socialWhat shapes #Immunotherapy response in #ESCC?
A single-cell immune atlas reveals central memory T-cell depletion in tumours and identifies PD-L1⁺ #macrophages and CD39⁺ tumour-infiltrating T cells as clinically relevant immune features.
@sigtrans-sttt.bsky.socialItaconate connects cellular metabolism with #Inflammation and redox balance.
This review explores the context-dependent actions and therapeutic potential of the IRG1/ACOD1–itaconate axis across inflammatory, metabolic, immune, and #malignantdiseases.
@sigtrans-sttt.bsky.socialT cell exhaustion and #Senescence impose distinct barriers to #Cancer #Immunotherapy.
This review explores their molecular hallmarks and emerging immune-rejuvenation strategies for checkpoint blockade and adoptive cell therapies.
@sigtrans-sttt.bsky.socialCan immune checkpoint therapies developed for #Cancer #Immunotherapy restore metabolic balance?
This review explores PD-1/PD-L1-mediated immunometabolic regulation in #Obesity,
#Diabetes, and thyroid disease and its therapeutic potential.
@sigtrans-sttt.bsky.social#Infection and #Hypoxia converge on the PHD1–TRIM21–CDC20 axis to drive #Aneuploidy and #Chemoresistance, while CDC20 stabilization limits securin and MCL1 accumulation, reduces chromosomal imbalance, and restores #Chemosensitivity.
