Excess p50 induces Arp1-dependent dynactin clusters containing the assembly factor VezA pubmed.ncbi.nlm.nih.gov/42814601/ #cryoEM

Extracellular Vesicle-Bound Bacterial Toxin Pneumolysin Triggers Membrane Engagement and Damage Beyond Canonical Pore Formation pubmed.ncbi.nlm.nih.gov/42814767/ #cryoEM

Natural Asp-tRNA Synthetase Fragment Targets Myofibroblasts to Abrogate Tissue Fibrosis pubmed.ncbi.nlm.nih.gov/42815638/ #cryoEM

RNA engineering approaches to aid high-resolution structure determination of medium- to large-sized RNAs pubmed.ncbi.nlm.nih.gov/42815639/ #cryoEM

We do not claim that cryo-tides will solve all your #cryoEM sample prep issues, but it certainly helped us in several instances. The advantage of this approach is that it is trivial to obtain the peptides, they induce negligible background and are compatible with small targets...

We show that the addition of synthetic peptides - which we refer to as cryo-tides - to #cryoEM samples can protect them from denaturation and can mitigate preferred orientation issues.

Those who had a careful look at the methods section of our work on the #cryoEM structure of the CDK11-cyclin L-SAP30BP complex will have noticed that we added a short peptide to our sample before freezing. If you wonder why...

...a lot of people have asked me about our cryo-tides and how they help with preserving particles during cryo-EM grid preparation...and here we go #cryoem: www.biorxiv.org/content/10.6...

Structural basis of nucleosome remodeling by archaeal RNA polymerase during transcription elongation www.biorxiv.org/content/10.64898/2026.09.29.754952v1 #cryoEM

Structural mechanism of Gasdermin E-mediated mtDNA release from apoptotic mitochondria www.biorxiv.org/content/10.64898/2026.09.29.755391v1 #cryoEM

cryoWEight: Conformational ensembles from cryo-EM particle images with weighted ensemble simulations www.biorxiv.org/content/10.64898/2026.09.28.755042v1 #cryoEM

Edge Electrostatic Inhomogeneity Correlates with Hysteresis and Localized Charging in Lithographically Defined Graphene Nanoribbon Devices pubmed.ncbi.nlm.nih.gov/42809637/ #cryoEM

Intense Pulsed Light Sintering of Cu@Ag Core-Shell Nanoparticles: Durable Flexible Electrodes and Electroluminescent Visual Feedback pubmed.ncbi.nlm.nih.gov/42809750/ #cryoEM

Extra-nasal odorant receptors: molecular mechanisms and therapeutic implications pubmed.ncbi.nlm.nih.gov/42807750/ #cryoEM

ProNA3D: Distance-Based Analysis of Nucleic Acid-Containing Interfaces pubmed.ncbi.nlm.nih.gov/42808009/ #cryoEM

Deciphering Transporter-Mediated Drug Interactions Affecting Marbofloxacin Residues in Sheep Milk: From In Silico Predictions to In Vivo Validation pubmed.ncbi.nlm.nih.gov/42808499/ #cryoEM

Mechanisms of substrate recognition and catalysis in a mammalian phosphatidylserine synthase 2 pubmed.ncbi.nlm.nih.gov/42809401/ #cryoEM

Lashing architecture in a meshed cocoon of a lichen-feeding moth Cyana (Lithosiini: Erebidae) pubmed.ncbi.nlm.nih.gov/42810076/ #cryoEM

Cryo-EM Structures Reveal Upstream DNA Interactions within the Mitochondrial Transcription Initiation Complex pubmed.ncbi.nlm.nih.gov/42810682/ #cryoEM

De novo minibinders targeting RH5 achieve nanomolar inhibition of blood-stage malaria replication www.biorxiv.org/content/10.64898/2026.09.28.755224v1 #cryoEM