IRAK1 coordinates #Chemoresistance and #ImmuneEvasion in #NSCLC by regulating ABCB1/ABCC1 and LXRα–ABCA1 signaling, while its inhibition restores cisplatin sensitivity and enhances T-cell-mediated tumor killing.
@sigtrans-sttt.bsky.social
@sigtrans-sttt.bsky.socialIRAK1 coordinates #Chemoresistance and #ImmuneEvasion in #NSCLC by regulating ABCB1/ABCC1 and LXRα–ABCA1 signaling, while its inhibition restores cisplatin sensitivity and enhances T-cell-mediated tumor killing.
@sigtrans-sttt.bsky.socialAge-related regenerative loss can compromise repair after liver injury.
Hepassocin activates #AMPK via ANXA2–ERK–p90RSK–LKB1 signaling, countering hepatic #Senescence and impaired #Autophagy while supporting regeneration in the aging liver.
@sigtrans-sttt.bsky.socialMitoferrin-1 sustains a NET histone–TLR9–IFNAR1 circuit that rewires neutrophil metabolism and promotes inflammatory tissue damage, revealing a strategy to restrain pathogenic responses while preserving #Phagocytosis.
#STTT #OpenAccess: doi.org/10.1038/s413...
#Inflammation #ChronicInflammation
@sigtrans-sttt.bsky.socialME1 is a direct L-lactate sensor that connects #Lactate signaling with HDGF-associated EMT and ME1–LDHB-mediated metabolic adaptation, shaping tumor plasticity across heterogeneous metabolic conditions.
@sigtrans-sttt.bsky.socialBenzofuran-based #MolecularGlues induce aberrant head-to-head STING oligomerization, disrupting canonical signaling and suppressing interferon and inflammatory responses, revealing a therapeutic strategy for STING-driven #Autoinflammatory diseases.
@sigtrans-sttt.bsky.socialCould targeted nanomedicine protect the brain by restoring mitochondrial function?
In a #ParkinsonsDisease model, peptide-targeted #Nanoassemblies enable nose-to-brain delivery, promote mitochondrial biogenesis and #Neuroprotection, and reduce #Neuroinflammation.
@sigtrans-sttt.bsky.socialSMG1 and DNA-PK phosphorylate NRF2 under mild #OxidativeStress, weakening KEAP1 binding and activating #Antioxidant programs that suppress #Ferroptosis, revealing a redox stress–intensity-dependent switch in #Cancer cell fate.
@sigtrans-sttt.bsky.socialBCL9 drives the MerTK–ERK–SPP1 macrophage M2 program in #PulmonaryFibrosis, while its inhibition reprograms macrophage–fibroblast crosstalk toward fibroblast #Lipogenesis, supports AT2 cell expansion and attenuates #Fibrosis.
@sigtrans-sttt.bsky.socialOrthodontic mechanical forces activate Piezo1⁺ macrophage–B-cell signaling and pathogenic IgM release, driving systemic #Inflammation, #LiverDysfunction and impaired distal #BoneRepair, while metabolic intervention reverses these effects.
@sigtrans-sttt.bsky.socialPAK4 phosphorylates YAP at T428, promoting its stabilization, nuclear accumulation and transcriptional activity to drive #HepaticStellateCell activation, while genetic or pharmacological PAK4 inhibition attenuates #LiverFibrosis.
@sigtrans-sttt.bsky.social#WorldLymphomaAwarenessDay | September 15, 2026
#Lymphoma research continues to uncover #tumor signaling and therapeutic targets to support precision treatment.
#STTT publishes peer-reviewed research in molecular mechanisms and translational medicine.
Read the latest: www.nature.com/sigtrans/
@sigtrans-sttt.bsky.socialAlu-mediated SPAST deletion disrupts SLC30A6 expression and ZnT6-dependent #Golgi zinc transport, linking zinc dyshomeostasis and Golgi fragmentation to protein aggregation and a targetable vulnerability in #Neurodegeneration.
@sigtrans-sttt.bsky.socialTRAP1 drives #Cancer-associated adipocyte reprogramming and #Chemoresistance in #BreastCancer.
This study demonstrates that targeting mitochondrial TRAP1 suppresses pro-tumorigenic crosstalk and enhances #Chemotherapy efficacy.
@sigtrans-sttt.bsky.socialChenodeoxycholic acid restrains tumor growth and potentiates antitumor immunity via TGR5-dependent dendritic cell activation. This study highlights metabolic modulation as a promising strategy for #Cancer #Immunotherapy.
@sigtrans-sttt.bsky.socialThis review maps the IGF/IGFR signaling network and its crosstalk with PI3K–AKT, #MAPK/ERK and other pathways, connecting context-specific signaling to diverse diseases and opportunities for targeted therapies. #Cancer
@sigtrans-sttt.bsky.socialRead how β-arrestins control spatial #PTH1R signaling by dampening plasma membrane activity and promoting #Endosomal responses, explaining ligand-specific biological outcomes in skeletal development. @WashU @harvardmed
@sigtrans-sttt.bsky.socialβPIX depletion in AT2 cells suppresses Wnt/β-catenin signaling, impairing alveolar epithelial stemness and promoting #Senescent transitional cells and collagen-producing #Myofibroblasts that drive #PulmonaryFibrosis.
@sigtrans-sttt.bsky.socialLoss of KLF4 can facilitate #ImmuneEvasion in #EsophagealCancer.
This study links KLF4 downregulation to impaired MHC class I antigen presentation and shows that restoring KLF4 can enhance response to PD-1 blockade.
@sigtrans-sttt.bsky.socialBacteria-derived PAMPs can reprogram macrophage responses against #Cancer cells.
This study shows that PAMP-decorated cancer cells activate pattern recognition receptor pathways, enhancing macrophage #Phagocytosis and antitumor activity.
@sigtrans-sttt.bsky.socialMetastatic organotropism shapes #LungAdenocarcinoma progression.
This study identifies tumor, immune and stromal signatures associated with organ-specific #Metastasis, highlighting #Biomarkers and #TherapeuticTargets.
