This work was enabled by the amazing community @stanford-chemh.bsky.social @stanfordchemistry.bsky.social @stanfordmedicine.bsky.social, and by collaborators @corsello.bsky.social and Nathanael Gray!

On the horizon, converting changes in protein abundance into programmable outputs could allow both discovery and reprogramming of biology to respond to endogenous signals and cues in new ways. Looking forward to the future of RTA!

This approach can: 1) enable measurement of small changes in protein abundance or changes in native levels of proteins, and 2) power high-throughput multiplexed screens for molecules which alter protein abundance (such as molecular glue degraders).

Excited our ratiometric transcriptional activation (RTA) work led by postdoc Dr. Melissa Gray is out online today in Cell @cp-cell.bsky.social! Measurements determine what we can discover in biology; we use RTA to turn protein abundance changes into amplified signals in live cells.