The archaeon Sukunaarchaeum mirabile, associated with dinoflagellates, has a genome of only 238 kbp🧬🤯
#archaea #symbiosis #eukaryotes #protists #MicroSky
@currentbiology.bsky.social
www.cell.com/current-biol...

1/ Our paper, “Enhancer binding kinetics explain transcription factor hub formation,” is now published! Here we set out to understand why transcription factors form bright clusters or “hubs” in the nucleus, and whether those hubs actually control gene activity.
tinyurl.com/38uf8348

Zeng et al, 2026. Transcription factors read a second regulatory code in chromatin www.biorxiv.org/content/10.6...
"our findings establish that TFs interpret two complementary layers of genomic information: the primary DNA sequence and a second code written into the nucleosome
architecture"

Our latest paper on building models of cell fate decisions -with David Rand, Marine Fontaine & @joadelas.bsky.social- combines developmental biology, dynamical systems theory and bioinformatics. I wrote a short piece to summarise it & explain ideas behind the approach

briscoelab.org/blog-quantif...

We are looking for a research assistant! Come join the team: www.jobs.ac.uk/job/DSZ826/r...

NEW PREPRINT!
An evo-devo look at how new cerebellar nuclei are made. Spoiler: it’s all driven by region-specific excitatory progenitors in the early rhombic lip; inhibitory neurons fill in later. If you care about brain evolution or cerebellar development, check it out: tinyurl.com/CNdevelopment

Our paper tying up some loose ends in our understanding of temporal patterning is out now! 🧠🪰 We show a single transcription factor (Tailless/TLX) terminates the temporal cascade across multiple neural stem cell lineages in the fly brain! journals.biologists.com/dev/article/...

Our latest: Dynamic Landscape Analysis of cell fate decisions provides predictive models of neural development from single-cell data

From Marine Fontaine and @joadelas.bsky.social with David Rand in @plosbiology.org

A thread 🧵
doi.org/10.1371/jour...