The fun part: we had been working with H37Rv without realizing this. A discussion with Heran made the two stories click. Together, the papers connect copper sensing, cysteine metabolism, redox homeostasis and Mtb fitness.
Kudos to Wendy, Florence, Daisy and all co-authors.

@asm.org #Tuberculosis

Independently, @heran.bsky.social’s lab found that CysK2 is required for copper resistance—and that H37Rv carries a hypomorphic S93G allele that helps explain its unusual copper sensitivity. A hidden strain peculiarity with big consequences.
📖 shorturl.at/gzFxj

𝐓𝐰𝐨 𝐬𝐭𝐮𝐝𝐢𝐞𝐬, 𝐨𝐧𝐞 𝐬𝐭𝐨𝐫𝐲: 𝐜𝐨𝐩𝐩𝐞𝐫, 𝐜𝐲𝐬𝐭𝐞𝐢𝐧𝐞 𝐚𝐧𝐝 𝐫𝐞𝐝𝐨𝐱 𝐚𝐝𝐚𝐩𝐭𝐚𝐭𝐢𝐨𝐧 𝐢𝐧 𝑴. 𝒕𝒖𝒃𝒆𝒓𝒄𝒖𝒍𝒐𝒔𝒊𝒔

Our new @mbio.bsky.social paper shows that copper reaches intracellular M. tuberculosis and strongly induces CysK2, a cysteine synthase linking copper sensing to redox adaptation and persistence.
📖 shorturl.at/PSDbk