Alex Holehouse

@alexholehouse.bsky.social

Associate Prof. at WashU School of Medicine; biophysics/biochem/evolution of intrinsically disordered proteins. How does nature encode function without a stable structure? We work in vivo / in vitro / in silico. He/him.
https://www.holehouselab.com/

@msuskiewicz.eurosky.socialReposted by @alexholehouse.bsky.social

Happy to share our preprint on a subset of ZBTB BTB domains as highly efficient natural SUMO 'supersubstrates'. The work was spearheaded by a great postdoc, El Hadji Cisse, with input from other team members and in collaboration with @defossezlab.bsky.social and @ucagne.bsky.social

@carlbergstrom.comReposted by @alexholehouse.bsky.social

An Iranian friend told me about their sorrow when American bombs fell on their universities. But then, my friend explained, they looked at what was happening to US universities—and realized they got off easy by comparison.

@waliianhydro.bsky.socialReposted by @alexholehouse.bsky.social

Abstract submissions are OPEN! Share your research at the 2nd Annual WALII Virtual Symposium and connect with researchers exploring anhydrobiosis and desiccation tolerance.

Deadline: October 9, 2026
Submit your abstract: bit.ly/4xkAOqL

Promotional graphic for the 2nd AnnualWALII Symposium, “Exploring Life Without Water,” featuring a desert landscape. The graphic provides abstract submission guidelines, including a one-page PDF or Word document with title, authors, affiliation, and abstract. Submission deadline is October 9, 2026.
@alexholehouse.bsky.social

Huge congrats to the many authors who over MANY years worked on this (but especially @karaehunt.bsky.social , @trevorbrandt.bsky.social, Karina, @shaharsu.bsky.social and @remenecker.bsky.social.

www.nature.com/articles/s41...

Alex Holehouse@alexholehouse.bsky.social

New (well, very old, but 100% updated) preprint: Rational design of disordered proteins for systematic sequence-to-function investigation Work done in collaboration with @shaharsu.bsky.social lab - check out the three (3) threads from the folks who did the work!

nature.comRational design of disordered proteins for sequence–function investigation - NatureGOOSE enables the design and testing of thousands of disordered protein region sequences to reveal distinct sequence-to-function relationships.
@alexholehouse.bsky.social

Papers are like buses... You wait for ages, then two come along at once.

Huge congrats to @bornanovak.bsky.social and @jefflotthammer.bsky.social for pushing and driving every aspect of this work, preprinted ~1 year ago to the day (Friday before BPS), now published!

www.nature.com/articles/s41...

Borna Novak@bornanovak.bsky.social

Excited to announce the newest member of the flock - STARLING (conSTruction of intrinsicAlly disoRdered proteins ensembles efficientLy vIa multi-dimeNsional Generative models). www.biorxiv.org/content/10.1...

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nature.comAccurate predictions of disordered protein ensembles with STARLING - NatureThe deep learning model STARLING can generate accurate ensembles of intrinsically disordered regions of proteins using only protein sequence as input.
@alexholehouse.bsky.social

Pleased to share the final version of this behemoth of a paper, now finally published. I guess I can retire now?
www.nature.com/articles/s41...

More functional data, many thousands of words removed, and a few other updates from last year's preprint.

Alex Holehouse@alexholehouse.bsky.social

We’re pleased to share our substantially updated (more below on that…) version of our manuscript exploring the relationship between conservation in sequence/function for intrinsically disordered regions (IDRs) www.biorxiv.org/content/10.1...

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nature.comSequence and chemical specificity define the functional landscape of intrinsically disordered regions - Nature Cell BiologyLangstein-Skora, Schmid, Huth et al. propose that intrinsically disordered region functionality can be driven by the interplay between linear binding motifs and contextual chemical characteristics suc...