Spectacular paper from @seth-shipman.bsky.social out in Mol. Cell. The perfect journal club paper.
Reverse transcribed ssDNA derepresses translation of a retron antiviral protein: Molecular Cell www.cell.com/molecular-ce...

@vram142.bsky.social
PI @ Gladstone Institutes & UCSF. Molecular technologies & the genomics / molecular biology / biochemistry of gene regulation. Views here mine & do not represent those of my affiliated institutions.
Spectacular paper from @seth-shipman.bsky.social out in Mol. Cell. The perfect journal club paper.
Reverse transcribed ssDNA derepresses translation of a retron antiviral protein: Molecular Cell www.cell.com/molecular-ce...
Now that we have moved coasts, I am thrilled to share that the ChromEvo (Raman) lab is officially open at UMass Boston π
We ask how CHROMatin EVOlution leads to functional innovation and we are hiring at multiple levels. Read on and share with folks who maybe interested
chromevoramanlab.github.io
Fragmentation patterns of human telomeric chromatin in plasma cfDNA www.nature.com/articles/s41...
π πππ
First Bluesky post for my new preprint! Super fun project with guidance from @abbybuch.bsky.social and @willowcoyote.bsky.social. We applied saturation mutagenesis to the Lamin A protein in #hiPSC derived cardiac cells to uncover cell type-specific mutation effects 1/ www.biorxiv.org/content/10.6...
1\ We know a bit about how 3D chromatin interactions are formed, but what do we know about how they are disrupted? We asked this question in our latest preprint: doi.org/10.64898/202..., focusing on the massive loss of promoter interactions during neuronal differentiation.
π¨ New preprint from the Rendeiro lab!
We mapped human tissue aging at single-cell resolution: 3.5 billion cells, 16 organs, 980 donors, spanning the adult lifespan. Led by @e-abila.bsky.social
We are recruiting a postdoctoral fellow to study DNA damage repair via the homologous recombination pathway using quantitative cell biology approaches. The position will be initially supported for two years by the MSU Research Foundation Postdoctoral Scholars program. Please share! 1/5
your starter pack for Single Molecule Genomics!
Why you should do it (or not) - How you should do it. Collective effort with @vram142.bsky.social @stirlingchurchman.bsky.social @naltemose.bsky.social A Stergachis M Stadler W Greenleaf @embl.org rdcu.be/PmzSEV529GRa
Everything you wanted to know about single-molecule epigenomics but were too afraid to ask! Wonderful to co-write (h/t ENORMOUS lift by @arnaudkr.bsky.social) this primer on our nascent field. Also, a π― example of wonderful colleagues building something *together*, not in competition =)
π§« Weβre hiring a staff/research scientist to develop new experimental approaches that capture cell state dynamics. Join us in Heidelberg, details + application here:
embl.wd103.myworkdayjobs.com/EMBL/job/Hei...
Closes September 30th
Excited to share our new paper