@labwilhelm.bsky.social
Research group studying metabolic and dietary control of mucosal immunology - led by Dr. Christoph Wilhelm at the University of Bonn
@labwilhelm.bsky.socialCongratulations to first authors Fotis Karagiannis and Rafa Theodorou
@labwilhelm.bsky.socialWe show that excess lipids in obesity suppress ACC1 in adipose ILC2s. Our findings also point towards an unexpected role of ACC1 in maintaining citrate shuttling and the NAD⁺/NADH balance.
@labwilhelm.bsky.socialHow does obesity disrupt ILC2 function and adipose tissue hoemostasis? In our latest study, we identify acetyl-CoA carboxylase 1 (ACC1) as a critical metabolic regulator of adipose ILC2 maintenance and function.
@labwilhelm.bsky.socialWe show that excess lipids in obesity suppress ACC1 in adipose ILC2s and identify and unexected role of ACC1 in maintaining citrate shuttling and the NAD⁺/NADH balance.
