@thelazarlab.bsky.social
From antibiotic-resistant to genotoxic bacteria We study how pathogens evolve, interact with hosts and respond to antibiotics and drug combinations AMR | virulence | colibactin | single-cell profiling | high-content microscopy | drug interactions
@thelazarlab.bsky.socialMALVINA is not just a method for us, but a story of questions, teamwork, coffee and millions of cells.
We wrote down how the project grew from one simple question into a @natcomms.nature.com study.
Read the Behind the Paper story, and follow us
communities.springernature.com/posts/one-qu...
@thelazarlab.bsky.socialWhat can MALVINA be used for?
Beyond measuring whether bacteria survive, MALVINA shows what they do to human cells. This single-cell, machine-learning approach could support pathogen profiling, probiotic discovery, drug testing and virulence-aware toxicity studies.
👉 www.nature.com/articles/s41...
@thelazarlab.bsky.socialAcross millions of cells, we show that virulence is not always a fixed trait of a strain. It is shaped by host cells, neighbouring microbes and drugs. Huge thanks to Terézia Kovács, Bence Bognár, Szilvia Juhász and all co-authors!
@thelazarlab.bsky.socialMALVINA combines high-content microscopy and machine learning to follow infection cell by cell: which cells bacteria enter, how strongly they accumulate, and whether they cause DNA damage. Across millions of cells, very different infection patterns emerged.
@thelazarlab.bsky.socialCounting bacteria is not enough.
To understand what makes a bacterium dangerous, we need to see what it actually does when it meets human cells.
Our MALVINA study is now out in @natcomms.nature.com
www.nature.com/articles/s41...
@thelazarlab.bsky.socialSome scientific connections are even better in person! 🇵🇹
At #GIMMFest, our lab members Bognár Bence and Nándor Kovács presented their research, exchanged ideas with Roy Kishony and finally met our consortium partner @isabelgordo.bsky.social.
Great science, great people! 🦠✨
@thelazarlab.bsky.socialWe study antibiotic interactions, evolution of resistance, virulence and host–pathogen interactions — from invading host cells to damaging DNA. Hello, Bluesky! Web:https://lazargroup.start.page/
