ERR: DPP1 inhibitors reduce exacerbations and may slow progression of bronchiectasis, validating inflammation as a key therapeutic target. Further investigation into their long-term efficacy, safety and treatment benefit across populations is needed. https://bit.ly/3UnM9s1

More than 50 students and trainees benefitted from free registration and mentorship at this year’s #ERSCongress!

New for this year, each student was assigned an ERS Early-Career Member to provide 1:1 mentorship throughout the event!

Read more: https://bit.ly/4yIg2Tx

Inflammasomes are central to respiratory diseases; however, to date, there is currently no clear reference publication that summarises the role of different inflammasomes and therapeutics in respiratory disease. This review addresses this knowledge gap. https://bit.ly/4fFnAzf

October is #PCDAwarenessMonth 🌍

Primary ciliary dyskinesia (PCD) is a rare genetic condition where cilia in the airways do not move properly. @European_Lung has a range of resources available which healthcare professionals can share with their patients: https://bit.ly/4hPK6oM

Eur Respir Rev: Physiologically relevant infection models should be benchmarked against clinical samples using omics data and quantitative accuracy scores to obtain clinically relevant insights into Pseudomonas aeruginosa cystic fibrosis lung infections. https://bit.ly/3TWeENm

This ERJ Open Research editorial discusses the article on DNA methylation in bronchiectasis by Perea et al. showing that severe bronchiectasis is associated with a distinct whole-blood DNA methylation signature, and discusses the importance of the findings https://bit.ly/3SGjvSw

European Respiratory Review: Concurrent use of opioids and stimulants are rising. This public health concern is a call to action for further research investigating the mechanisms these drugs act on to advance prevention and treatment. https://bit.ly/4xzTJOG

Join us in Heidelberg, Germany next month for an ERS skills course on interventional bronchoscopy! Through hands-on workshops, participants will have the opportunity to practice live flexible and rigid bronchoscopy on airway models.

Learn more: https://bit.ly/4ybkdWx

Apply now for a new ERS Research Seminar – Identifying a path towards implementation of respiratory oscillometry into research and clinical care!

This seminar aims to identify key research gaps and establish priorities for future work. Learn more:
https://bit.ly/3UcLv0S

ERJ Open Research: Bronchiectasis shows distinct immune dysregulation, with depletion of FCER1G+ NK-cells and reduced CXCR4 in monocytes, highlighting innate immune disruption as a driver of disease progression https://bit.ly/4mhw9C2

The latency between smoking debut and lung cancer diagnosis in Norwegian ever-smokers is much longer than what has previously been reported, and time to diagnosis in women and current smokers is shorter compared to men and former smokers, respectively https://bit.ly/4e64HDv

ERJOR: In chronic airway diseases, initiation of inhaled antibiotic therapy is largely driven by microbiological isolation, and occurs both in stable conditions and during periods of clinical instability, with exacerbations remaining an important trigger https://bit.ly/3OPpUJv

A multicomponent asthma care model delivered sustained reductions in preventable hospitalisations and meaningful improvements in asthma control and quality of life for rural children. The model offers a replicable approach for underserved populations. https://bit.ly/3OZaB0S

ERJOR: Noninvasive ventilation during exercise improves endurance and reduces dyspnoea (showing a significant dose–response relationship) and PCO2 in COPD. Evidence supports its targeted use during pulmonary rehabilitation, particularly in severe disease. https://bit.ly/48EElXb

ERJ Open Research: Among patients with severe pulmonary hypertension associated with COPD, acute pulmonary vasoreactivity identified a subgroup with better haemodynamic response to approved PAH therapies and long-term survival https://bit.ly/4tt1y7h

ERJOR: BMPR2 mRNA expression is significantly reduced across all assessed PH subgroups, indicating a potential general impairment of BMPR2 signalling. BMPR2 mRNA and BMP10 protein expression in blood may serve as novel biomarkers for disease severity. https://bit.ly/4trUrvD

In high-altitude residents diagnosed with PAH, low-dose SOT via portable concentrator did not improve 6MWD or dyspnoea perception, most likely due to insufficient flow during exercise, exertional mouth breathing and the weight of the concentrator https://bit.ly/4vNxFzU

European Respiratory Journal: snRNA-seq analysis of RAS lungs revealed the general principle of an entity-spanning composition of the usual fibrotic niche consisting of aberrant basaloid cells, ectopic COL15A1+ pVECs, and CTHRC1+ fibroblasts https://bit.ly/3QdPRmf

Join ERS, PATS & Société de Pneumologie de Langue Française (SPLF) in Nairobi on 10–11 October for The world's first lung health resolution

https://www.ersnet.org/events/the-worlds-first-lung-health-resolution-mobilising-a-network-of-advocates-in-africa/

Two weeks left to apply to organise your own research seminar!

Apply now: https://www.ersnet.org/science-and-research/research-seminars/