Seung Hwan Lee’s team developed dBhCas12b-ABE, a Cas12b adenine base editor targeting T-rich PAMs that suppresses indels to 0–0.04% and offers tunable editing windows. 🧬🤖 #CRISPR #BaseEditing #Cas12b #MolecularTherapy #GeneEditing #ChungAngUniversity

#CAS researchers developed a lambda Red-assisted #CRISPR/Cas9 editing system in #Agrobacterium tumefaciens, achieving up to 100% precise editing efficiency and engineering immune-evading strains that boost plant transformation. 🌿🤖 #PBJ2026 #PlantBiotech #GenomeEditing

#Jiayang Li and Hong Yu’s team used #CRISPR promoter saturation editing on OsHMA3 to disrupt repressor OsRF2b binding, creating a transgene-free knock-up allele that reduces rice grain cadmium by 40.7% with zero yield penalty. 🌾🤖 #RiceGenomics #PlantBiotech2026 #CadmiumSafety #PromoterEditing

Anhui Science and Technology University researchers established a seasonality-free mature embryo transformation engine in bread wheat, achieving up to 2.5% stable transformation and 37.8% #CRISPR/Cas9 editing efficiency at the Rht12 locus. 🌾🤖 #WheatGenomics #TissueCulture #MatureEmbryo

Traver Hart’s team evaluated a 77,000 dual-gRNA Cas12a library on bioRxiv, revealing that dual-target locus excision operates at very low efficiency in mammalian screens due to asynchronous cleavage dynamics. 🧬🤖
#CRISPR #Cas12a #bioRxiv2026 #MDAnderson #GeneEditing #FunctionalGenomics

NWAFU researchers developed PrePssmCas, a classifier fusing ESM1b language embeddings and evolutionary PSSM profiles to achieve 97.98% accuracy in distinguishing Cas from non-Cas proteins. 🧬🤖
#CRISPR #Bioinformatics #NWAFU #ProteinLanguageModels #CasDiscovery #AIinBiotech

#UCBerkeley researchers developed PERCEPT, using self-immolative reduction-sensitive linkers to decorate #CRISPR #RNPs with PEG, escape peptides, and targeting ligands for targeted in vivo editing across brain, retina, muscle, and lung tissues. 🧠🤖 #GeneEditing #bioRxiv2026 #PERCEPT #BaseEditing

#CAAS researchers combined k-mer GWAS and autotetraploid #CRISPR editing in #alfalfa to decode the #MsCBF8-MsGolS2 module, which coordinates dynamic stomatal closure, ROS scavenging, and raffinose synthesis for enhanced #drought survival with zero yield penalty. 🌿🤖 #ForageBreeding

Researchers discovered that the superior #wheat allele #TaNPF7.6-A1mod (V431A) sequesters repressor TaJAZ1 in the cytoplasm to unleash TF TaEIL3, driving a positive feedback loop that enhances tonoplast nitrate efflux, tillering, and grain yield without #protein dilution. 🌾🤖

Meng et al. developed #BPGA, an enzyme-free in vivo Bxb1-ParA recombinase system in standard DH5α E. coli that iteratively stacks #multi-gene plant vectors, demonstrated by assembling a 9-TU, 41.551 kb andrographolide pathway construct. 🌿🤖 #PlantPhysiology #SyntheticBiology #MetabolicEngineering

The UK's #ARIA has committed £54M to explore whether #geneediting, genomics, and AI can help wild species adapt faster than climate change, through 13 projects still confined to controlled research. aria.org.uk/opportunity-...

Shahid Mansoor’s team reviewed the evolution of plant #primeediting from PE1 to AI-designed PE8, highlighting pegRNA stabilization, cis-regulatory expression tuning, and PE-recombinase systems for predictive crop breeding. 🌾🤖 #PlantBiotech2026 #TrendsInPlantScience #CropGenomics #AIinBiotech

#WEHI researchers developed #Partita, a high-density mouse genome-wide #CRISPRa library (263,460 sgRNAs), mapping #cancer dependencies, Irx5-driven venetoclax resistance, and in vivo MYC-synergistic oncogenes (Runx2/Runx3/Csf1r). 🐭🤖 #ScienceAdvances2026 #DrugResistance #InVivoScreening

CAS researchers assembled a 568.88 Mb #T2T gapless genome of Medicago lupulina and established its first #CRISPR/Cas9 editing platform, targeting MlPINNA1 to generate a 5-leaflet pentafoliate mutant phenotype. 🌿🤖
#MedicagoLupulina #JIPB2026 #LegumeGenomics #ForageBreeding #AgBiotech

Huazhong Agricultural University researchers deployed transcript-specific #CRISPR editing to uncouple overlapping genes at the OsRLCK280/NAT1 locus, proving #OsRLCK280 governs blast #immunity and BR signaling while #antisense NAT1 independently regulates #grainlength. 🌾🤖 #RiceGenomics #KabinXie

Researchers demonstrated that deleting Domain-V from gymnosperm #PdeLAZY1 abolishes its upright-promoting activity but fails to complement poplar tac1 knockouts, disproving the single-step deletion hypothesis for #TAC1 evolution. 🌲🤖 #PlantGenomics #PoplarBiotech #PlantArchitecture #Forestry

#JenniferDoudna’s team discovered #VIPR, a pre-CRISPR viral #RNA-guided system that uses an ancestral RAMP protein and a noncontiguous "1-nt skip" pairing code (NN-x-NN) for PAM-free programmable gene repression. 🧬🤖 #Science2026 #CRISPR #UCBerkeley #GeneEditing

#PekingUniversity researchers discovered PmCas12m—a naturally nuclease-dead miniature Cas nuclease—and engineered #xCas12m (581 aa), enabling #single-AAV packaging of xCas12m-CRISPRoff for durable in vivo HBV epigenetic silencing in mice. 🧬🤖 #Epigenetics #CRISPRoff #GeneTherapy #HBV

The UK has approved its first precision-bred crop — a vitamin D–biofortified tomato from the #JohnInnesCentre delivering roughly the vitamin D of 2 eggs per fruit — while #WiMi supports #knockout, #baseediting, and #knock-in transformation across 30+ crop species and genetic backgrounds.

Researchers established a 17.5% efficient stable transformation platform in 'Taishan Red' #pomegranate, proving that the SG6 R2R3-MYB factor #PgMYB10 master-regulates #anthocyanin biosynthesis by co-activating six key structural genes to drive a 5.4-fold pigment surge. 🍎🤖 #WoodyFruit