This week’s #PAIN Featured Image is Chandra et al.’s schematic model illustrating how P06 activates GPR37L1 on satellite glial cells. This pathway, disrupted in neuropathic pain conditions, also regulates IL-1β production to confer potent analgesia bit.ly/4ik5PqO

Kwamo et al. present data supporting an endogenous analgesic role of vasopressin 1 receptors in limiting pain after spreading depolarization and suggest vasopressin 1 receptors are involved in mechanisms of migraine headache cessation #PAIN bit.ly/4ik5OTM

Start your #WC2026 learning before Bangkok with recorded Refresher Courses across pain research, clinical care, policy and education. IASP members: US$29/course. Non-members: US$49/course: bit.ly/47JecFO #PainEducation

Miller et al. find that responder outcome over time is a novel acute pain endpoint that provides improved interpretability over sum of pain intensity differences and eliminates the need to impute pain scores after rescue medication #PAIN bit.ly/4ipVw4q

Help shape NeuPSIG 2027 in Helsinki. Workshop proposals are open across neuropathic pain and itch. The submitting speaker must be an IASP and NeuPSIG member. Deadline: 16 Nov 2026, 16:59 GMT: bit.ly/3TwqqhQ #NeuPSIG2027

Burns et al. examine relationships between treatment mechanisms to reveal that mechanisms change in definable sequences relative to each other; the magnitude of mechanism-to-mechanism relationships is predictive of outcomes. Learn more in #PAIN bit.ly/4c4gdPI

14 days to Bangkok. Past attendees: What is one piece of advice or one must-do you would share with a first-time attendee? Explore #WC2026: bit.ly/3Uhm7qO 26-30 October 2026 | BITEC

Polgár et al. provide evidence that 2 molecularly defined vertical cell populations are required for itch, but not for neuropathic pain. Learn more in #PAIN bit.ly/4ik5ODg

In this week’s #PAIN Featured Image, Guerra-Armas et al. depict potential mechanisms underlying IVR-induced pain relief, including changes in attention, neuroplasticity, autonomic regulation, and antinociception. Learn more at bit.ly/4xbsLxf

Lee et al. find that patients with peripheral neuropathic pain exhibited cortical disinhibition to noxious heat, manifested by a flatter electroencephalography spectrum and alpha-band event-related desynchronization. Learn more in #PAIN bit.ly/4g8ebAt

Allen et al. find that parabrachial NPY Y1 receptor neurons drive the sensory dimension of neuropathic pain, and their activity is critical to the development and persistence of hypersensitivity. Learn more in #PAIN bit.ly/45FBefR

Van Diepen et al. find that pain affects over 50% of advanced pancreatic cancer patients and can be reduced by chemotherapy, highlighting the need for regular pain assessments and personalized management. Learn more in #PAIN bit.ly/4wPzsEg

Wu et al. find that melatonin may provide modest pain relief and improve sleep in chronic musculoskeletal pain, but evidence remains limited and supports its use as an adjunct rather than a primary treatment. Learn more in #PAIN bit.ly/4ik5O6e

In this week’s #PAIN Featured Image, massih.bsky.social et al. propose a model of the hippocampus in pain, where vulnerability factors converge on the hippocampus to shape its structure and function. Learn more at bit.ly/4ihZLz1

Chao et al. find that inhibiting monoacylglycerol lipase alleviates pain-induced depression and sensory hypersensitivity through distinct CB1 receptor mechanisms. Learn more in #PAIN bit.ly/4ik5QuS

Rau et al. assert that the diagnostic criteria included in the ICD-11 are ill-suited for diagnosing pediatric patients with chronic primary headache and propose implementing pediatric coding notes. Learn more in #PAIN bit.ly/4xdsv0H

@johnstreicher1 et al. find that inhibition of heat shock protein 90 (Hsp90) in mouse spinal cord leads to protein kinase C-β signaling in calcitonin gene-related peptide neurons, which mediates enhanced opioid antinociception. Learn more in #PAIN bit.ly/4wJC7iL

Lillo Vizin et al. find that experimental post-traumatic headache is selectively driven by trigeminal orexin B/orexin receptor 2 (OX2R) signaling in male mice. Learn more in #PAIN bit.ly/4xdRQYr

In this week’s #PAIN Featured Image, Su et al. illustrate trigeminal sensory pathways, with a focus on pain and proprioception. Learn more at bit.ly/4ik5NPI

In this week’s #PAIN Featured Image, Su et al. illustrate trigeminal sensory pathways, with a focus on pain and proprioception. Learn more at bit.ly/4ik5NPI