#ROADMAP 🚨

Early-onset colorectal cancer is rising. This Roadmap explores current gaps in our understanding of risk factors and presents a conceptual framework for discovery + prevention.

Plus, it's free to read! Please share!

🚨 #REVIEW 🚨

Chen and Zou discuss how chronic replication stress shapes cancer biology and how emerging therapies are targeting the pathways that enable tumour cells to survive it.

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#Comment 🚨
How can we ensure that breakthroughs in breast cancer research improve outcomes for every woman? Miriam Mutebi examines the challenges and opportunities in translating innovation into equitable patient benefit.
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Review🚨
Viral mimicry activates antiviral immune responses through endogenous nucleic acids in the cytosol. Chen et al. discuss how tumours suppress these responses and why escape from #ViralMimicry may be a key feature of tumour evolution.
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#Editorial 🎉Time to celebrate 25 years of #NatureReviewsCancer🎉
On this milestone we contemplate how our view of cancer has changed over the past 25 years and speculate on what the future holds.🥳
Thanks to our authors & readers who made this possible!
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http://dlvr.it/TVdJXj

🎉 Our 25th Anniversary Issue is now live! 🎉🥳
Featuring #Reviews on
- 3D tumour atlases
- The systemic impact of EVs
- Pyroptosis & antitumour immunity
#Roadmap on
- Early-onset CRC prevention
Plus #Viepoints #Comments &#WorldView

Check it out 👇
http://dlvr.it/TVcqwv

#Review 🚨
How can #PopulationGenetics help decode tumour evolution? This Review discusses how mutation, selection and drift shape cancer genomes and how evolutionary models can reveal tumour dynamics and trajectories from sequencing data.
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#ViewPoint 🎉 Celebrating 25 years of NRC!
Six leaders in cancer research reflect on the ideas that transformed their field, those that fell short of expectations and the challenges that remain.
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http://dlvr.it/TVZmk1

#Review🚨
Read how genotype and phenotype co-evolve during cancer progression with insights from single-cell multimodal technologies and phylogenetic approaches, revealing vulnerabilities in mutant clones.

@landau.bsky.social
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#Review🚨
#Neutrophils can impact tumor growth. This Review explores their role in tumor progression and #metastasis, compares it to other biological contexts, and discusses new strategies for targeting neutrophil biology in cancer.

@stanfordpress.bsky.social

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🚨 Early-onset colorectal cancer is on the rise globally. This #Roadmap highlights knowledge gaps, proposes a model for risk factor discovery, and emphasizes the importance of patient engagement and transdisciplinary science in combating this trend.
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Review🚨
Ciriello, Oricchio &Co discuss how remodelling of the 3D structure of #chromatin in cancer is both a cause and a consequence of genetic and epigenetic alterations and highlight how chromatin 3D conformation might be exploited for diagnosis and therapy.
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