@yalegenetics.bsky.social
Department of Genetics at Yale School of Medicine. Making transformative discoveries that advance human health.
@yalegenetics.bsky.socialWhy does chromosome instability drive breast cancer?
A new CRISPR screen across 3,752 genes identified 90 cancer drivers embedded in chromosomal imbalances, revealing how DNA alterations select specific oncogenes to fuel tumor heterogeneity 🧬🔬
www.nature.com/articles/s41...
@yalegenetics.bsky.socialScientists engineered lipid nanoparticles coated with mannose sugar to sneak past the blood-brain barrier and deliver therapeutic mRNA directly to glioblastoma tumors. Once inside, the mRNA instructs cancer cells to produce a tumor-suppressing protein.
pmc.ncbi.nlm.nih.gov/articles/PMC...
@yalegenetics.bsky.socialA drug targeting tau, the protein behind Alzheimer's tangles, slowed cognitive decline by up to 26% in a phase 2 trial. It works by binding to the mRNA that encodes tau, interrupting its production. A promising new front in Alzheimer's research 🧠
www.science.org/content/arti...
@yalegenetics.bsky.socialResearchers used AI to design synthetic CRISPR enzymes that don't exist in nature, aiming to outperform natural ones. By bypassing the limits of evolution, AI-designed molecular scissors may accelerate gene editing across medicine & agriculture 🤖🧬✂️
www.nature.com/articles/d41...
@yalegenetics.bsky.socialAnimal research is emotionally demanding - yet early-career scientists can feel that they must stay silent about it. Three researchers share advice on building resilience & caring for yourself without leaving the science you love 👇Read more here👇
www.nature.com/articles/d41...
@caseywdunn.bsky.socialReposted by @yalegenetics.bsky.socialInterested in joining our lab (dunnlab.org) and YIBS as a postdoc? I'm looking for someone to work on siphonophores, diversity in the open ocean, or natural history. If that's you, please reach out this week to discuss a nomination for the Donnelley Postdoc Fellowship - yibs.yale.edu/donnelley-fe...
@yalegenetics.bsky.socialKnowing which genes are active in a tumor isn't enough. Yale Genetics' Profs. Wang & Muzumdar are combining spatial transcriptomics & genetic screening to map how cancer genes shape their surrounding tissue, backed by new NCI funding
👇Read more here👇
www.linkedin.com/posts/yalege...
@yalegenetics.bsky.socialHow can we scale personalized genetic therapies for rare diseases? Yale Genetics' Caroline Hendry & Yong-hui Jiang examine the FDA's new framework for individualized treatments, outlining the groundwork needed to turn promising science into accessible medicine 👇
www.linkedin.com/posts/applyi...
@noonanlab.bsky.socialReposted by @yalegenetics.bsky.socialNew preprint from the lab! Using a humanized mouse model, we found that a Human Accelerated Region drives heterochronic changes in craniofacial and limb development (apologies for the re-post, we needed to adjust the thread a bit):
www.biorxiv.org/content/10.6...
@yalegenetics.bsky.social