ACR Journals

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Official journals of the American College of Rheumatology: Arthritis & Rheumatology Arthritis Care & Research ACR Open Rheumatology SoMe Editor: Karen Costenbader, MD, MPH

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A 47-year-old man was referred with suspected giant cell arteritis because of progressive bilateral swelling along the superficial temporal arteries. Over several weeks, firm, indolent, non-tender elastic masses developed first on the right and subsequently on the contralateral side (A)

Firm, indolent, non-tender elastic masses developed first on the right and subsequently on the contralateral side (A). Color duplex ultrasonography showed unspecific morphology with torqued and thickened (arrowhead) temporal arteries (B). Supra-aortic MR angiography demonstrated concentric thickening of the temporal arterial walls with surrounding edema (“halo sign”, arrowhead) and surrounding edematous perivascular tissue (arrows), findings suggestive of vasculitis (C). Temporal artery biopsy was performed. Histopathologic examination revealed angiolymphoid hyperplasia with eosinophilia (ALHE; also termed epithelioid hemangioma) (D–F)
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Interviews with adults with RA (n=24), rheumatology clinicians (n=6), and physical therapists (n=6) explored how physical therapy is used in routine RA care in the US. Despite strong evidence supporting PT in RA management, participants described PT as inconsistently used in routine care

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Greater positive affect was associated with better physical function in early RA, even after adjusting for pain intensity, depressive symptoms, and other clinical factors.

The association between positive affect and physical function was strongest at lower pain levels

AC&R
doi.org/10.1002/acr....

Interaction between positive affect and pain intensity on PROMIS Physical Function in early RA
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Investigating survival outcomes in older adults with axSpA and concomitant cancer showed older adults with axSpA and colorectal cancer had higher overall survival, while those with breast, prostate, or lung cancer had similar survival outcomes vs controls without axSpA

AC&R
doi.org/10.1002/acr....

Hazard ratio tree plots for 5-year overall survival (a) and cancer-specific survival (b) in the colorectal cancer cohort.
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New study shows MSC therapy alleviates systemic sclerosis, with significantly reduced skin fibrosis & stabilized lung function Integrated multiomics revealed that MSCs drive immunometabolic reprogramming by repairing oxidative phosphorylation defects in cDC2 cells and restoring immune homeostasis

Mesenchymal Stromal Cells Fuel Immunometabolic Reprogramming of Type 2 Conventional Dendritic Cells to Alleviate Systemic Sclerosis. Graphical abstract made using BioRender
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New investigation shows colon epithelial-derived CD4+ T cells retain a tolerogenic phenotype while undergoing tissue-specific transcriptional reprogramming after entering extraintestinal sites

Results suggest a mechanistic framework for gut-joint axis in spondyloarthritis

doi.org/10.1002/art....

Extraintestinal Reprogramming of Colon-Derived CD4+ Intraepithelial Lymphocytes Reveals a Mechanism Underlying the Gut-Joint Axis. Graphical abstract made using BioRender
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In a Swedish national cohort with newly diagnosed SLE 2006-2022, the role of oral GC exposure in organ damage differed across organ domains. For several domains, especially cardiovascular damage, GC exposure over a 3-year period was required to fully capture the association with organ damage risk

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