In patients with severe tricuspid regurgitation and heart failure, transcatheter tricuspid-valve repair plus medical therapy was superior to medical therapy alone in reducing hospitalizations for heart failure and deaths. Full TRIC-I-HF trial results and Research Summary: https://nej.md/4ilZJGr

In five pediatric heart transplantations, a rapid-recovery technique involving oxygenated preservation enabled the use of donated hearts without reanimation. All recipients had normal biventricular function by day 7. Full study results: https://nej.md/4j5oEi0

A 35-year-old woman presented with a 20-day history of a nipple ulcer. On examination, there was ulceration, crusting, and a yellowish exudate on the right nipple. Read the full case details: https://nej.md/4hN2P4p

This randomized trial examined whether adding a multicancer early-detection blood test to usual care reduces late-stage cancer diagnoses in adults 50 to 77 years of age. Research findings from the NHS-Galleri trial are summarized in a new Quick Take video. https://nej.md/4iZFheW

I got to reflect on 26 years of sepsis resuscitation studies in @nejm.org, and came to argue that Michael Pollan was right: “Re-establish perfusion. Not too high. However is safest for you.”

My editorial on ARISE/FLUIDS

www.nejm.org/doi/full/10....

New @nejm.org Voices: how I write an introduction to a research manuscript

“My first piece of advice…: write your introduction backwards.

“My second piece of advice: innovate in your ideas, not in the structure of how you present the ideas.”

voices.nejm.org/doi/full/10....

A 64-year-old woman with no known medical history presented to clinic with a 4-year history of worsening low back pain and difficulty walking. Read the full case details and submit your answer or see how others responded: https://nej.md/IC10082026

The TRIC-I-HF trial tested transcatheter tricuspid-valve repair plus medical therapy as compared with medical therapy alone in severe tricuspid regurgitation in patients at high risk for heart-failure events. Research findings are summarized in a new Quick Take video. https://nej.md/4xW6DWZ

A 58-year-old woman was admitted to the hospital for rapidly progressive bilateral hearing loss. PET-CT showed bilateral uptake along the internal obturator muscles bilaterally as well as along the sartorius muscles, without mass or lymphadenopathy. Learn more: https://nej.md/4zbx4t3

Case Record of the MGH: A 19-year-old woman presented with fever and cervical lymphadenopathy. The white-cell count was 2900 per microliter (reference range, 4000 to 11,000), and the lactate dehydrogenase level was elevated. A diagnosis was made. Read the full case details: https://nej.md/4y2AhtQ

A 2-month-old boy was brought to the ED after a seizure. The scalp hair was sparse and coarse. Serum copper and ceruloplasmin levels were markedly low. MR angiography showed tortuosity of the intracranial and extracranial arteries. Read the full case details: https://nej.md/4hNpn59

A new review summarizes advances in therapy, including approval or expanded use of targeted agents, improved outcomes with antibody–drug conjugates and immunotherapy, and growing reliance on molecular profiling. Read the Review Article: https://nej.md/47AOTFX

Karl Deisseroth, MD, PhD, winner of the Nobel Prize in Physiology or Medicine 2026, describes the science behind a study of intravitreal delivery of an AAV vector encoding a light-gated ion channel in 10 blind patients with advanced retinitis pigmentosa. Read the editorial: https://nej.md/476T5x1

In the PIONEER study, the safety of ganglion cell–directed optogenetic therapy was evaluated in 10 participants with blindness due to advanced retinitis pigmentosa. Full study results: https://nej.md/4j18UMZ

Science behind the Study: Optogenetics in Sight https://nej.md/476T5x1

Among patients with HIV-1 suppression while receiving bictegravir–emtricitabine–tenofovir alafenamide (B/F/TAF), switching to weekly islatravir–lenacapavir was noninferior to continuing daily B/F/TAF in maintaining suppression. Full phase 3 ISLEND-1 trial results: https://nej.md/4b4s7sh

In a new NEJM Voices blog post, @iwashyna.bsky.social presents a step-by-step guide to writing a concise introduction to a clinical research manuscript. Read the post and sign up for email alerts: https://nej.md/4AQ1ySQ

As a primary care physician who receives many messages on the online patient portal, would you recommend billing for such messaging or not billing? Read the case vignette and options and vote: https://nej.md/3TCTF2r

Inconveniences during hospitalization are often unavoidable, but many of its frustrations can be eased through better communication, clearer expectations, and other practical improvements in inpatient care.

Read the latest NEJM Voices blog post by @mkittlesonmd.bsky.social: https://nej.md/4ybawHD

A 58-year-old woman with previously stable hearing impairment was admitted for rapidly progressive bilateral hearing loss. She reported no headache, vertigo, tinnitus, or dizziness. Read the full case details and authors’ commentary: https://nej.md/4zbx4t3

You speak rheumatology??

Our latest video in partnership with @glaucomflecken.bsky.social summarizes the REPLENISH trial that evaluated the efficacy and safety of secukinumab for the treatment of polymyalgia rheumatica. Read the full study for free: https://nej.md/DrG50

#Rheumatology