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Christos Argyropoulos MD, PhD, FASN πŸ‡ΊπŸ‡Έ 0kale/acc

@christosargyrop.bsky.social

2.4k Following10k Followers

Division Chief, Nephrology UNMHSC (im)personal views & account #zerokale Firm believer : caveat emptor & stupidity is immoral Random thoughts about #nephrology #stats #bioinformatics #perl #HPC #nanopore #RNAseq #covid19 #amateurcoding #ButlerianJihad

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@christosargyrop.bsky.socialOct 11, 2026, 1:43 PM

Kimi K3 "bribing the hamster" hits again!
(This is the AGI you were promised by the #AI scammers, people)

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@christosargyrop.bsky.socialOct 10, 2026, 2:51 PM

Finerenone hit a pharmacokinetic/pharmacodynamic sweet spot in CKD. Also suggested by the need to use higher doses in heart failure trials. An effective drug is not created out of a MoA , but by the combo MoA + PK + PD (or MoA + ADME) @stephensenn.bsky.social @hswapnil.medsky.social

@edgarvlermamd.medsky.networkOct 10, 2026, 12:25 PMReposted by @christosargyrop.bsky.social

PRO/CON debate: nonsteroidal (finerenone) vs. steroidal (spironolactone/ eplerenone) mineralocorticoid receptor antagonists in CKD: progress, pragmatism, and remaining uncertainties ca. 2026 from @ckj-era.bsky.social
#Nephpearls #Cardiorenal #NephSky

πŸ‘‰ pubmed.ncbi.nlm.nih.gov/42682722/

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@karluchipa.bsky.socialOct 10, 2026, 2:24 PMReposted by @christosargyrop.bsky.social

I was encouraged by MDs on the DataMethods.org board to put this together:

How #AI Can Help (or just worry) Patients.

Feel free to distribute.

drive.google.com/file/d/1mckg...

@hswapnil.medsky.socialOct 10, 2026, 2:14 PMReposted by @christosargyrop.bsky.social

Vincristine-Induced Acute Flaccid Paralysis as a Mimicker of Guillain Barre syndrome in a Patient With Posttransplant Lymphoproliferative Disorder - Kidney International Case Reports www.kicasereports.org/article/S311...

June issue highlights

@christosargyrop.bsky.socialOct 9, 2026, 12:00 PM

Pork ribs in red chili

@christosargyrop.bsky.socialOct 9, 2026, 2:48 AM

I have become vegan (by proxy) @madgreek.bsky.social @cubiclogic.bsky.social

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@christosargyrop.bsky.socialOct 9, 2026, 2:44 AM

Defund the HOAs

@christosargyrop.bsky.socialOct 8, 2026, 10:28 PM

Group thinking when the group is not thinking, is bad.

@christosargyrop.bsky.socialOct 7, 2026, 11:43 PM

The other thing in that figure that is worth noting is the egfr "decline" which probably is just correction of hyperfiltration

@christosargyrop.bsky.socialOct 7, 2026, 11:42 PM

A1c still sucked at 8, there are other microvascular outcomes that are responsive to glycemia control

@christosargyrop.bsky.socialOct 7, 2026, 5:57 PM

This was not clear in the presentation lol. Will read the arxiv. We already have a theory of smooth analogs of the Kolmogorov superpositions tho but unfortunately this is not what is done

@christosargyrop.bsky.socialOct 7, 2026, 12:35 AM

I am glad I bought about 10 to 12 TB of 1tb ssd when the price was low. I use my Barracudas in a RAID0 configuration for biointormatics (all the data reside on the cloud)

@christosargyrop.bsky.socialOct 6, 2026, 1:46 PM

If this was the same lecture that you sent me some time ago, it had a shortcoming: he assumed/hoped the space being searched has a unique maximum which can never hold

@christosargyrop.bsky.socialOct 6, 2026, 1:40 PM

Same. I don't spin at least 2 of them. The externals are not as bad though

@christosargyrop.bsky.socialOct 6, 2026, 1:39 PM

3x markup for my crappy 8TB Barracuda Compute

@christosargyrop.bsky.socialOct 6, 2026, 2:22 AM

I bought these drives 1.5 - 2 years ago, inflation is real

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@weaselproof.bsky.socialOct 5, 2026, 5:56 PMReposted by @christosargyrop.bsky.social

Web devs learned 15 years ago that there is no such thing as anonymized data. Now the AI bros gonna relearn that about training data. Or more properly, go to absurd lengths to avoid learning it

@kthorjensen.bsky.socialOct 5, 2026, 5:29 PMReposted by @christosargyrop.bsky.social

chat is this good

best_of_web 1d
A customer just tried to use an employee discount code that ChatGPT gave her. I work at a high-end clothing store and clocked in to my manager telling me about the most unhinged interaction from yesterday. A woman walked in asking if she could use a 40% off code she got online. We don't have any sales running, so my manager looks at the screen and realizes ChatGPT straight up handed this woman a real employee's internal ID number.
@christosargyrop.bsky.socialOct 5, 2026, 8:02 PM

Age verification coming to NM soon?

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