True

Sorry to hear 😞

I didn't even know it was possible to die multiple times

It's interesting when you ask people to imagine what their life would be like if they were transported historically to the past. Some people seem to assume they'd be in the relatively well-off 1-2% and it would go fine for them. Meanwhile I just assume I'd be a secluded female peasant.

Thank you!! Yes 🤦‍♀️ I meant to bring that up and had it in my notes, but promptly forgot. I don't think it's most though, and sometimes, even if a protein is missing, you can use siRNA to silence an opposing protein to compensate for it. That's the strategy with fitusiran for hemophilia, for example

That's right, I'm Fr-

Historical regions furthest from me makes sense too

🫣 It must be my views on baklava sandwiches that are compatible with theirs

Good to know which historical figures are furthest from me politically

But we think it’s just a matter of time before they can be used to target other organs too. Will siRNA treat diseases of other organs? And what’s the catch? Listen to our latest episode of HARD DRUGS to find out!

Today, siRNA drugs are largely used to treat liver diseases, partly because that’s the easiest starting point. And they are extremely effective at it. One example is for cholesterol: siRNA drugs reduce PCSK9 levels by around 70%, reducing cholesterol levels by 50-60%, beyond the effect of statins.

• Long-lasting: some drugs last for months, even half a year, with a single injection • Off-the-shelf: they typically don’t involve complicated surgeries or procedures, because of the way they’re delivered in the body

What’s even better is that siRNA drugs are: • Potentially tunable, meaning you could reduce the production of a protein, rather than silencing it entirely • Programmable, meaning you can quickly switch out which gene it targets by changing its sequence

- Cardiovascular diseases, silencing proteins like PCSK9 that raise cholesterol - Cancers, by silencing proteins that help tumour cells grow, survive, metabolize, metastasize, or resist treatment - and more!

siRNA drugs can ‘silence’ harmful genes in the body. And there are lots of cases where you might want to silence genes: - Infectious diseases, where you can silence pathogen proteins or human proteins that pathogens depend on - Rare genetic diseases, to silence the production of mutated proteins

Unfortunately I think this predates AI

😂😂😂