Stand Up for Science!

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We mobilize the fight for science and democracy - because science is for everyone! 🧬🧪🌎

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The Trump Admin is harassing Fauci to scare scientists from speaking up against the administration's war on science, sowing public distrust in scientists and public health experts.

We are standing up for Fauci. JOIN US by signing our petition at the link: zurl.co/RCYN8

The graphic displays a photo of Dr. Anthony Fauci and the red Stand Up for Science logo. The graphic reads: "BREAKING NEWS; Senate Republicans voted to hold 85-year old public health patriot Dr. Anthony Fauci in contempt of Congress. SIGN OUR PETITION TO CONGRESS IN SUPPORT OF DR. ANTHONY FAUCI AND AMERICAN PUBLIC HEALTH. LINK IN BIO!"
@keeganlannon.bsky.socialReposted by @standupforscience.net

When I wanted to survey a group of students, the IRB manager wouldn’t let me do it in class because the potential for emotional harm for those who felt coerced into filling out the survey. But sure…this seems okay.

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The FDA now recognizes more than 100 drugs whose effects are shaped by your genes. While genetic testing is not yet a routine step in medicine, it's hard not to picture a future where it is. All thanks to continuous monitoring of approved medications, where a failure turns out to be a breakthrough.

ext reads "THE SUCCESS: The FDA now recognizes more than 100 drugs whose effects are shaped by your genes. Making genetic testing routine still has hurdles, but it’s easy to imagine a future where your doctor checks your DNA before writing a prescription, the way they check your blood pressure today." Right hand side of the graphic features 70's inspired multi colored line design with a pill bottle spilled open.
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This pill works by depending on an enzyme to switch it on. However after release, monitoring revealed that some people taking it were still having heart attacks and stroke. Turns out their genes carried a version of the enzyme that wasn't great at turning the drug on.

Text reads "A pill that does nothing until your liver wakes it up The clopidogrel in the pill is essentially inactive. It’s a pro-drug, a kind of sleeper agent. That job falls to an enzyme in your liver called Cyp2C19. Once the drug is switched on, it latches onto platelets and keeps them from clumping together into clots. The active form is so unstable that it couldn’t be made into a pill, so your body has to build it on the spot." Right hand side of graphic features a graphic of red blood cells trailing down the side.Text reads"When the pill fails Once millions of people were taking clopidogrel, a problem emerged. Some patients took it exactly as prescribed and still had heart attacks and strokes. The reason ended up being in their genes. Some people carry versions of the Cyp2C19 gene that make them poor metabolizers, so the pill never gets switched on. Others are partial converters who activate it, but not well. Roughly 10% of people are poor metabolizers, and the share is higher in some populations, such as people from Oceania." Right hand side features an illustrated graphic of a DNA double helix.
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Aspirin had great success as a medication, but also had side effects. Scientists went looking for a better option and found ticlopidine, then later clopidogrel, which went on to become one of the best-selling drugs in the world.

ext reads "From happy accident to blockbuster Aspirin works, but it has side effects, so drug companies went looking for better options. In 1970 they hit something unexpected. One compound, ticlopidine, had no anti-inflammatory power at all, but it was a potent inhibitor of platelet aggregation, which makes it a blood-clot blocker. It reached the US market in 1991 for patients at high risk of clot-related cardiovascular events." To the right is a graphic of red blood cells trailing down the sideText reads "Then came the catch In roughly one in a few thousand patients, ticlopidine caused dangerously low platelet counts. Luckily, backup candidates were already waiting, and one of them, clopidogrel (Plavix), won FDA approval in 1997. It went on to become one of the best-selling drugs in the world." Bottom right features the same pill bottle that is spilled open with pills coming out, as featured on the first page.
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This series, Traces, is our way of starting the conversation behind how treatments are discovered and developed, one story at a time. This week, sharing the story of one of the most widely sold medications in the world.

Text reads "Treatments & cures take forever to make. Which can make people frustrated, as they feel their tax dollars are not being properly spent. It’s a long & tedious process that is often not discussed with the people who fund it. So, we are starting the conversation, one story at a time. This week, we’re sharing the story of the most widely sold medication in the world." Bottom right features a photo of a microscope with glassware behind it.
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Why does the same blood thinner drug work for one patient and fail for another? Let's talk about one of the most widely sold medications in the world and how it's development changed the game forever. 🧪 🧵

Blue graphic with text that reads "Why does the same blood thinner drug work for one patient and fail for another? How we learned why patients respond differently to the same drug. Part 7" To the right is a 70's inspired graphic with yellow, orange, red, and blue curved lines leading to a pill bottle with pills coming out of it.
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Our team is already talking with members of Congress, scheduling briefings, engaging with the international community, and exploring every possible route to stop this study. To help augment our efforts, we need you to demand your members of Congress to stop to this unethical “study”.

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This is a gross violation of human rights and the use of bad science against some of the most vulnerable people in the world." – Dr. Colette Delawalla, Founder and CEO of Stand Up For Science

@standupforscience.net

"We stopped this unethical study the first time and we’ll do it again. These are innocent babies and the last thing they need is RFK, Jr. doing another of his pet project experiments on them in pursuit of ‘evidence’ to support his dangerous anti-vax beliefs....

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