Recent structural, functional and dynamic research on the bacterial melibiose permease MelB has revealed significant insights into the symport mechanisms of Na+-coupled MFS transporters #CryoEM #XRayCrystallography #HDXMS doi.org/10.1107/S205...

A practical approach for ligand validation during structure determination is outlined and key pitfalls are illustrated by re-examining several deposited PDB entries #LigandValidation #XRayCrystallography #StructureGuidedDrugDiscovery doi.org/10.1107/S205...

Exploration of the acetyl-pyrrole scaffold led to the identification of BAZ2A-binding compounds assuming a peculiar, almost enclosed, conformation, as determined by X-ray crystallography #BAZ2A #Bromodomains #XRayCrystallography doi.org/10.1107/S205...