A novel ADAM17-based strategy enables T cell-autonomous control of CAR signaling via a 15-aa motif, leading to reduced CAR expression and enhanced regulation post-activation. #Tcellresearch #CARtherapy PMID:42143019, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00504-0 #Medsky 🧪

Study finds TCF1 alone doesn't define stem-like T cells in chronic disease; LEF1 and niche factors also crucial for T cell stemness in autoimmunity & chronic infection. #TcellResearch PMID:42385703, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00709-9 #Medsky #Pharmsky #RNA 🧪