#Targetome
Monocrotaline's reactive metabolite covalently modifies platelet IP receptor and PTEN, driving pulmonary hypertension; selexipag and rosiglitazone counteract vascular remodeling in rats.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0048
#PyrrolizidineAlkaloids

#Targetome
Retrospective analysis: 20.2% of Chinese older adults filled 2+ CPIC level-A drugs yearly; CYP2C19, SLCO1B1, CYP2C9 dominate coverage.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0043
#Pharmacogenomics #Polypharmacy #Geriatrics

#Targetome
Huperzine A restores striatal acetylcholine homeostasis and recruits a GABAergic circuit to improve cognition in vascular dementia mice.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0042
#VascularDementia #HuperzineA #NeuralCircuit

#Targetome
Immunosenescence destabilizes the bone marrow immune niche in osteoporosis; natural products may reprogram microenvironmental targets.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0040
#Osteoporosis #Immunosenescence #BoneMarrow #NaturalProducts

#Targetome
Spatial-seq 2.0 maps how Panax notoginseng versus ginseng saponins differently protect brain regions after acute ischemic stroke.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0038
#Panax #Stroke #SpatialTranscriptomics #Neuroprotection

#Targetome
Respiratory chain complexes as programmable therapeutic nodes: beyond ATP bioenergetics toward context-dependent metabolic reprogramming.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0037
#RespiratoryChain #Mitochondria #MetabolicReprogramming #DrugDiscovery

#Targetome
CLP290-mediated KCC2 activation restores gait, inhibitory neurotransmission, and metabolic balance across the neuromuscular axis in dystrophic mice.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0041
#Duchenne #KCC2 #Neuromuscular #Metabolomics

#Targetome
An integrated framework unites target fishing, single-cell multi-omics, and AI reasoning into a closed-loop workflow for natural product target discovery.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0036
#TargetFishing #SingleCellOmics #AIDrugDiscovery

#Targetome
Cytoskeletal checkpoints, not molecular catalogs, may govern microglial aging: Pfn1 and Arpc4 loss trigger divergent senescence and synaptic deficits.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0035
#Microglia #Cytoskeleton #BrainAging #Dementia

#Targetome
AI pharmacophore-transcriptomic framework repurposes CBD for ischemic stroke via NRF2/BMAL1-mediated antioxidant and angiogenic effects.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0034
#DrugRepurposing #IschemicStroke

#Targetome
Natural products as multi-target graft protectants: pairing nanocarrier delivery with machine perfusion to curb reperfusion injury in donor heart preservation.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0039
#HeartTransplant #GraftPreservation #Nanocarrier

#Targetome
CLDN18.2 emerges as a promising PDAC therapeutic target, with monoclonal antibodies, bispecific antibodies, CAR-T cell therapy, and antibody-drug conjugates showing clinical progress.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0033
#CLDN18.2 #TargetedTherapy