What's next for #lipid-based #RNA #delivery? This review covers rational vs combinatorial design, multiplexed formulation, #protein corona principles, biophysical mechanisms & #machine #learning approaches.

👉 doi.org/10.3390/phar...
#RNADelivery #LipidNanoparticles #Formulation #Nanomedicine

TU Munich researchers used RFdiffusion AI to create synthetic transfer vehicles (STV-C8) that outperform LNPs by >1,000-fold in RNA delivery and achieve in vivo CRISPR editing in pigs. 🧬🤖 #Nature2026 #RNADelivery #RFdiffusion #CRISPR #GeneTherapy #STVC8