How does the gut sense mechanical forces?
This review explores #Piezo1 and #Piezo2 in intestinal motility, barrier integrity and host–microbiota balance, while linking their dysregulation to #GIdiseases and cancers.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

In mice, removing both #Piezo1 and #Piezo2 slowed the maturation of dentin-forming odontoblasts and reduced Wnt/β-catenin signaling. Adding #Wnt10a restored odontoblast development in cultured tooth germs, connecting mechanical sensing with #tooth development.👇
www.nature.com/articles/s41...