Bulk transcriptome of 18 vs 3 mo🐭 cochlear pericyte
Aging➡️
⏫TGFβ signals➡️
⏬IGF-1 & SLC25A33 mito pyrimidine nucleotide transport
IGF-1 microinjection rescues #BloodLabyrinthBarrier ultrastructure & Age-related hearing loss🐭
@haoyin.bsky.social
@haoyin.bsky.socialBulk transcriptome of 18 vs 3 mo🐭 cochlear pericyte
Aging➡️
⏫TGFβ signals➡️
⏬IGF-1 & SLC25A33 mito pyrimidine nucleotide transport
IGF-1 microinjection rescues #BloodLabyrinthBarrier ultrastructure & Age-related hearing loss🐭
@febsj.bsky.social🔬 Burkhard et al. discussed how pericytes contribute to the synthesis and remodelling of the ECM in different pathophysiological conditions, and shared an atlas of the pericyte matrisome:
📕 Proteolytic remodelling of the extracellular matrix by pericytes ➡️ buff.ly/NhJzFIi
#pericyte #ECM #matrisome
