15. Harnessing transcriptional regulation of alternative end-joining to predict cancer treatment - Espín et al. doi.org/10.1093/narc... Links #hypoxia/HIF1α and #MYC to #PARP1/POLQ expression and alternative end joining, with combination-treatment effects in cancer cells. 16/18

2. RAD51C breast cancer-identified variants with attenuated homologous recombination function... Ganesan et al.
doi.org/10.1093/narc... #RAD51C variants retain partial #HR yet disrupt replication and accumulate gaps; a subset sensitizes cells to combined #PARP1 and #ATR inhibition. 3/18