Soares et al. find that ultraviolet-B-induced inflammation differentially sensitizes single recorded pig C-afferents fibers, particularly desensitizes C-tactile fibers while turning silent nociceptors hyperexcitable. Learn more in #PainReports bit.ly/47MjAYO

Gilbert et al. demonstrate that THIK2 channels, expressed in nonpeptidergic sensory neurons, exert an inhibitory control over neuronal excitability and reduce pain sensitivity in mice. Learn more in #PainReports bit.ly/4hP0YMj

Gilbert et al. demonstrate that THIK2 channels, expressed in nonpeptidergic sensory neurons, exert an inhibitory control over neuronal excitability and reduce pain sensitivity in mice. Learn more in #PainReports bit.ly/4hP0YMj

Barjandi et al. find that patients with regional, but not local, TMD myalgia show elevated intramuscular kynurenine pathway activation in response to exhaustive tooth-clenching, suggesting differential peripheral mechanisms. Learn more in #PainReports bit.ly/477AX6j

Yamada et al. identify the SLC6A3 rs2963257 A allele as a significant risk factor for chronic pain susceptibility in a case-control study of a Japanese population. Learn more in #PainReports bit.ly/3W4DeN1

Prokhorenko et al. find that astrocyte Ca2+ signaling mediated by store-operated Ca2+ entry is required for chronic pain and may be an important target for nonopioid pain therapeutics. Learn more in #PainReports bit.ly/4hsL6R2

Prokhorenko et al. find that astrocyte Ca2+ signaling mediated by store-operated Ca2+ entry is required for chronic pain and may be an important target for nonopioid pain therapeutics. Learn more in #PainReports bit.ly/4hsL6R2

Carvajal-Zamorano et al. find that zoledronic acid inhibits TRPV1 function, reduces nociceptive responses in preclinical models, and reveals a mechanistic basis for analgesia with potential clinical repurposing. Learn more in #PainReports bit.ly/4hYl8Vs

Tremblais et al. assessed the effects of a lack of control on pain perception and learning and found that experiencing uncontrollable pain leads to lower perceived pain and relief pleasantness. Learn more in #PainReports bit.ly/4aaXuRi

Li et al. developed a new single-session preventive psychological intervention targeting pain after surgery entirely based on experiences of patients and caregivers. Learn more in #PainReports bit.ly/4fFeuCU

Kaur et al. present a comprehensive synthesis of the findings from 29 studies on spinal cord stimulation. The results could serve as a valuable contribution in the spinal cord stimulation patient selection process. Learn more in #PainReports bit.ly/4dIKJ1n

Bradt et al. review use of electroencephalography globally to measure acute neonatal pain, initiate collaborations with key researchers in the field, and identify data for subsequent meta-analysis. Learn more in #PainReports bit.ly/4dOkIhh

Di Domenico et al find that childhood discrimination is associated w/ higher multisite pain odds across multiple discrimination subtypes, revealing dose-dependent relationship independent of socioeconomic factors, adverse childhood experiences #PainReports bit.ly/4fbfHlk

Di Domenico et al find that childhood discrimination is associated w/ higher multisite pain odds across multiple discrimination subtypes, revealing dose-dependent relationship independent of socioeconomic factors, adverse childhood experiences #PainReports bit.ly/4fbfHlk

In their 2-cohort analysis, Jaltare et al. find that women with painful diabetic neuropathy have higher pain, anxiety, sleep disturbance, and worse small-fiber dysfunction compared with men. Learn more in #PainReports bit.ly/3PMrcVN

Cheng et al. discuss motor deficit as a rare yet severe herpes zoster complication, more often diagnosed in men, characterized by a sensory loss phenotype and a poor prognosis. Learn more in #PainReports bit.ly/4u1UvC1

Bi et al. find that sleep disturbances and negative mood swings the day before an assessment can have a significant influence on ratings of perceived change the day after. Learn more in #PainReports bit.ly/3RPYBzD

Garcia et al. find that patients with facial pain disorders exhibited a heightened risk of suicide that was associated with considerable pain-related impairments. Learn more in #PainReports bit.ly/3PMrcoL

Mesaroli et al. used advanced diffusion MRI to identify increased anisotropy and reduced orientation dispersion in sensorimotor projection fibers in chronic low back pain, implicating altered neurite architecture. Learn more in #PainReports bit.ly/4vajjIR

Pontiff et al. find that higher estimated cardiorespiratory fitness is associated with lower odds of chronic pain and with more favorable changes in pain severity in the general population. Learn more in #PainReports bit.ly/4favaSH